The effect of geometric shape on the release properties of metronidazole from lipid matrix tablets
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the lipophilic matrix tablets of metronidazole were prepared with Cutina HR (hydrogenated castor oil), stearic acid, Compritol ATO 888 (glyceryl behenate) and Precirol ATO 5 (glycerol palmitostearate) in two different shapes; cylinder and hexagonal. Our first aim was to investigate the influence of the lipid excipients and geometric shape on the release behavior of metronidazole, and the second aim was to investigate the influence of tablet surface area/volume (SA/V) ratio on drug release from controlled release matrix tablets. In vitro release test was performed using a standard USP dissolution apparatus I. Hardness, surface/volume ratio and friability were determined. The hexagonal tablets were harder than the cylinder tablets. Stearic acid showed the highest release rates for both geometric shapes reflecting the highest surface area and the lowest SA/V ratio. According to power law analysis, the diffusion mechanism was expressed as a Fickian diffusion for all lipid matrix tablets. The square root of time relationship was operative for all tablets. Higuchi kinetic constants obtained with hexagonal tablets were higher than the cylinder tablets. As the type of lipid matrix, the geometric shape of the tablets was also effective on the diffusion and release kinetics. From the present study, it was shown that surface area and volume ratio may be used as parameters for the evaluation of the drug release profile. Copyright © 2009 American Scientific Publishers All rights reserved.
Açıklama
Anahtar Kelimeler
Fickian diffusion, Geometric shape, Lipid matrix, Metronidazole, Power law analysis, Release kinetics, Tablets
Kaynak
Journal of Biomedical Nanotechnology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
5
Sayı
4
