A new concept in the treatment of extravasation injury: controlled drug delivery systems
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Zerbinis Medical Publ
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: To investigate the effectiveness of the intralesionally injected controlled granulocyte-monocyte colony stimulating factor (GM-CSF) releasing system in widening refractory extravasation wounds. Methods: The determination of in vitro GM-CSF release from chitosan gel was the first, and in vivo effect of the molecule was the second step of the study. Thirty-five Wistar-Albino rats were randomly divided into 5 groups: 1) control group (adriamycin group) (n=7); 2) adriamycin + normal saline group (n=7); 3) adriamycin + chitosan group (n=7); 4) adriamycin + 1 mu g/mL GM-CSF-loaded chitosan group (n=7); and 5) adriamycin + 10 mu g/mL GMCSF loaded chitosan group (n=7). The wound area was measured macroscopically and histological examination was carried out for wound healing and tissue response to the polymer Results: The best healing process was observed with the controlled released GM-CSF groups (groups 4 and 5). The 1 mu g/mL GM-CSF loaded group showed superior wound healing than that of 10 mu g/mL GM-CSF loaded gels. This result was correlated with the in vitro study which also showed increased drug release in the 1 mu g/mL GM-CSF loaded group than the 10 mu g/mL GM-CSF loaded gels. Conclusion: This study suggests that GM-CSF, applied with controlled drug delivery system, can supply dynamic treatment options with long-lasting activity in single-dose administration.
Açıklama
Anahtar Kelimeler
adriamycin, chemotherapy, chitosan, controlled release, extravasation
Kaynak
Journal of Buon
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
15
Sayı
3
