Platelet function and insulin resistance in aged and middle-aged obese female patients
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
It is well known that obesity is associated with insulin resistance (IR), and IR may interact with platelet functions. Aging is also associated with IR and enhanced platelet aggregation (PA). Though platelet reactivity has been investigated in female individuals, to date there is insufficient data on PA in obese and elderly women for whom the physiological changes associated with aging may overlap the factors associated with obesity. Therefore we investigated PA and IR in obese aged and middle-aged female subjects. Thirty obese elderly women over 60 years of age and 30 middle-aged obese women under the age of 50 years with nonspecific complaints were enrolled in the study from internal medicine outpatient clinic. Anthropometric measurements, fasting blood glucose and insulin levels, and PA tests for collagen, epinephrine, and adenosine diphosphate were evaluated. Obesity was defined as body mass index (BMI) >30 kg/m2. Homeostasis model assessment of IR (HOMA-IR) index was calculated to estimate IR. PA tests were performed with a PA profiler. Mean age of the elderly and middle-aged women were 69.6±9.5 years and 38.6±10.5 years, respectively. Waist circumference and BMI were similar between two groups. Mean HOMA-IR index value and PA with epinephrine were higher in the elderly than the control group (P=0.04; P=0.01, respectively). There was a positive correlation between HOMA-IR and PA with epinephrine in the elderly. Insulin resistance and platelet function test for epinephrine increased with advancing age in obese women. Large-scaled studies are needed in this area.
Açıklama
Anahtar Kelimeler
Biyoloji, Alerji, Anatomi ve Morfoloji, Androloji, Anestezi, Odyoloji ve Konuşma-Dil Patolojisi, Biyokimya ve Moleküler Biyoloji, Biyofizik, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Kalp ve Kalp Damar Sistemi, Hücre Biyolojisi, Klinik Nöroloji, Yoğun Bakım, Tıp, Dermatoloji, Acil Tıp, Endokrinoloji ve Metabolizma, Gastroenteroloji ve Hepatoloji, Geriatri ve Gerontoloji, Sağlık Bilimleri ve Hizmetleri, Hematoloji, İmmünoloji, Enfeksiyon Hastalıkları, Tamamlayıcı ve Entegre Tıp, Tıbbi Etik, Tıbbi İnformatik, Tıbbi Laboratuar Teknolojisi, Genel ve Dahili Tıp, Adli Tıp, Tıbbi Araştırmalar Deneysel, Mikrobiyoloji, Nörolojik Bilimler, Kadın Hastalıkları ve Doğum, Onkoloji, Göz Hastalıkları, Ortopedi, Kulak, Burun, Boğaz, Patoloji, Pediatri, Periferik Damar Hastalıkları, Fizyoloji, Temel Sağlık Hizmetleri, Psikiyatri, Halk ve Çevre Sağlığı, Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme, Rehabilitasyon, Solunum Sistemi, Romatoloji, Spor Bilimleri, Cerrahi, Transplantasyon, Tropik Tıp, Üroloji ve Nefroloji
Kaynak
Medicine Science
WoS Q Değeri
Scopus Q Değeri
Cilt
7
Sayı
4
