Prognostic significance of the Ki–67 labeling index and p53 protein expression for patient with craniopharyngioma
Küçük Resim Yok
Tarih
2009
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Dergi ISSN
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Kraniyofarinjiyomalar histolojik olarak benign tümörlerdir. Yavaş büyüyen, lokal olarak invaziv, tedavisi sıklıkla zor olan rekürrens ve önemli morbiditeye neden olabilen intrakranial tümörlerdir. Bu tümörlerde klinik gidişi belirleyecek güvenilir morfolojik kriterler yoktur. Bu çalışmanın amacı kraniyofarinjiyomalarda rekkürrens için Ki-67 proliferasyon indeksini ve p53 protein ekspresyonunun prognostik değerini araştırmaktır. Kraniyofarinjiyomalı 47 hasta (29 erkek, 18 kadın, yaş dağılımı:4-74 ve ortalama yaş: 31.4±17.8 ) çalışmaya alındı. 9 olgu papiller olguda skuamöz, 38 olgu ise adamantinomatöz tipti. 10 hastada (% 21,2 ) tümör nüksetti (2-120 ay, ortalama 23,2 ay). Ki-67 indeksi % 0-12 arasında değişiyordu (ortalama % 1.68±2.7). 24 olguda p53 immunpozitiflik oranları %1-25, olgularin büyük çoğunluğunda (17 olguda) % 10'un altında boyanmıştı. Ki-67 indeksi ve p53 immunpozitifliği ile tümör rekürrensi ve histolojik subtip arasında istatistiksel olarak anlamlı bir korelasyon saptanmadı. Kraniyofarinjiyomaların çoğunda düşük Ki-67 etiketleme indeksi ve p53 immunpozitifliği sık görülen bir bulgudur ve tümor rekürrensini belirlemede prognostik değeri yoktur.
Craniopharyngiomas are histological benign tumors. Craniopharyngiomas are slowly growing locally invasive intracranial tumors that can generate considerable morbidity and recurrences that are often difficult to manage. Reliable morphologic criteria for predicting clinical outcome of these tumors are lacking. The aim of the study was to investigate the prognostic value of Ki–67 labeling indices and p53 protein expression for recurrence in craniopharyngiomas. A series of 47 patients with craniopharyngiomas (29 male and 18 female; age range:4-74 years, mean years:31.4±17.8) were reviewed. Nine cases were papillary squamous and 38 cases were adamantinomatous variant. Tumors recurred in 10 (%21.2) patients (range 2-120, mean 23.2 months). Ki–67 labeling indices varied from 0 % to 12 % (mean 1.68±2.7 %). The ratio of p53 staining was 1-25% in 24 cases, in most majority (17 cases) it was under 10%. Ki–67 labeling index and p53 immunopositivity showed no statistically significant correlation with tumor recurrences and histological subtypes. Low Ki–67 labeling indices and p53 immunopositivity are common findings in the majority of craniopharyngiomas. Ki–67 labeling indices and p53 expression of primary tumors did not have prognostic value to predict tumor recurrence.
Craniopharyngiomas are histological benign tumors. Craniopharyngiomas are slowly growing locally invasive intracranial tumors that can generate considerable morbidity and recurrences that are often difficult to manage. Reliable morphologic criteria for predicting clinical outcome of these tumors are lacking. The aim of the study was to investigate the prognostic value of Ki–67 labeling indices and p53 protein expression for recurrence in craniopharyngiomas. A series of 47 patients with craniopharyngiomas (29 male and 18 female; age range:4-74 years, mean years:31.4±17.8) were reviewed. Nine cases were papillary squamous and 38 cases were adamantinomatous variant. Tumors recurred in 10 (%21.2) patients (range 2-120, mean 23.2 months). Ki–67 labeling indices varied from 0 % to 12 % (mean 1.68±2.7 %). The ratio of p53 staining was 1-25% in 24 cases, in most majority (17 cases) it was under 10%. Ki–67 labeling index and p53 immunopositivity showed no statistically significant correlation with tumor recurrences and histological subtypes. Low Ki–67 labeling indices and p53 immunopositivity are common findings in the majority of craniopharyngiomas. Ki–67 labeling indices and p53 expression of primary tumors did not have prognostic value to predict tumor recurrence.
Açıklama
Anahtar Kelimeler
Nörolojik Bilimler
Kaynak
Journal of Neurological Sciences (Turkish)
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
3
