The effect of edothelium on the response to propofol on bovine coronary artery rings
Küçük Resim Yok
Tarih
1995
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the effect of propofol on isolated bovine coronary artery tone was studied in artery rings precontracted with PGF2?. Propofol, in concentrations of 10-6-10-5 M did not change vascular smooth muscle tone, but at high concentrations (10-4-10-1 M) produced relaxation in rings with intact endothelium. In rings denuded of endothelium or treated with methylene blue, propofol produced relaxation at 10-3-10-1 M concentrations, but there was a significant decrease in relaxation compared to endothelium intact rings. In the presence of a calcium agonist (Bay K 8644; 10-5 M), propofol produced constriction in rings denuded of endothelium. These results suggest that high concentrations of propofol may have vasorelaxant effect on bovine coronary artery and that these effects may be due to actions on the endothelium and mediated by calcium channels. Copyright © 1995 Acta Anaesthesiol Scand
Açıklama
Anahtar Kelimeler
bovine coronary artery, eudotheiium, Propofol
Kaynak
Acta Anaesthesiologica Scandinavica
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
39
Sayı
8
