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Öğe Antral/pyloric type hyperplastic polyp with prominent myoglandular features: a distinct subtype of gastric polyps(Springer, 2018) Doganavsargil, B.; Pehlivanoglu, B.; Vardar, R.; Ozdemir, H.; Sezak, M.; Ozutemiz, O.; Tuncyurek, M.Öğe Azygoesophageal fistula: a rare cause of upper gastrointestinal tract bleeding(Georg Thieme Verlag Kg, 2013) Gencdal, G.; Vardar, R.; Bozkaya, H.; Meral, C.; Parildar, M.; Ozutemiz, O.Öğe Correlation of immunohistochemistry on liver biopsy and serum HBVDNA levels(Elsevier Science Bv, 2008) Yilmaz, F.; Nart, D.; Vardar, R.; Gunsar, F.; Ersoz, G.; Karasu, Z.; Sertoz, R.; Erensoy, S.; Ilter, T.; Batur, Y.; Akarca, U. S.Öğe The diagnostic value of 24-h ambulatory intraesophageal pH-impedance in patients with laryngopharyngeal reflux symptoms(Wiley, 2015) Sakin, Y. S.; Vardar, R.; Sezgin, B.; Cetin, Z.; Alev, Y.; Yildirim, E.; Kirazli, T.; Bor, S.Öğe The diagnostic value of 24-h ambulatory intraesophageal pH-impedance in patients with laryngopharyngeal reflux symptoms(Wiley, 2015) Sakin, Y. S.; Vardar, R.; Sezgin, B.; Cetin, Z.; Alev, Y.; Yildirim, E.; Kirazli, T.; Bor, S.Öğe The diagnostic value of 24-h ambulatory intraesophageal pH-impedance in patients with laryngopharyngeal reflux symptoms(Wiley, 2015) Sakin, Y. S.; Vardar, R.; Sezgin, B.; Cetin, Z.; Alev, Y.; Yildirim, E.; Kirazli, T.; Bor, S.Öğe Effect of alginate in patients with GERD hiatal hernia matters(Oxford Univ Press Inc, 2017) Vardar, R.; Keskin, M.; Valitova, E.; Bayrakci, B.; Yildirim, E.; Bor, S.Alginate-based formulations are frequently used as add-on proton pump inhibitor (PPI) therapy to help control of heartburn and regurgitation. There are limited data regarding the mechanisms and effects of alginate-based formulations. We aimed to evaluate the effects of the sodium alginate intake and its likely temporal relations on intraesophageal reflux events byMII-pH in patients with and without hiatal hernia (HH). Fifty GERD patients (18 with HH, 32 without HH) with heartburn or regurgitation once a week or more common were included. After combined multichannel intraluminal impedance and pH-metry (MII-pH) had been performed, all patients were asked to eat the same standard meal (double cheeseburger, 1 banana, 100 g regular yoghurt, and 200 mL water with total energy value of 744 kcal: 37.6% of carbohydrates, 21.2% of proteins, and 41.2% of lipids) during two consecutive days. On separate random two consecutive days, all patients took 10 mL of sodium alginate (GA; Gaviscon Advance; Reckitt Benckiser Healthcare, Hull, UK) or 10 mL of water, 30 minutes after the refluxogenic meal. After eating refluxogenic meal, patients were examined 12 hour for basal conditions, 1 hour in upright, and 1 hour in supine positions. Alginate significantly decreased acid reflux after intake at the first hour in comparison to water in patients with HH (6.1 vs. 13.7, P = 0.004) and without HH (3.5 vs. 5.5, P = 0.001). Weakly acid reflux were increased at the first hour in patients with HH (3.4 vs. 1.3, P = 0.019) and without HH (1.7 vs. 5, P = 0.02) compared to water. There was no distinctive effect of alginate on the height of proximal migration of reflux events in patients with HH and without HH. Alginate decreases acid reflux events within a limited time period, especially at the first hour both in patients with and without HH. Alginate has no effect on the height of reflux events along the esophagus both in patients with and without HH.Öğe The effects of inhaler b-2 adrenergic agonists on esophageal high resolution manometry pressure metrics in asthma patients with inadequate symptom control(Wiley, 2015) Goksel, O.; Vardar, R.; Karakus, H. S.; Alev, Y.; Yildirim, E.; Erdinc, M.; Bor, S.Öğe The effects of inhaler b-2 adrenergic agonists on esophageal high resolution manometry pressure metrics in asthma patients with inadequate symptom control(Wiley, 2015) Goksel, O.; Vardar, R.; Karakus, H. S.; Alev, Y.; Yildirim, E.; Erdinc, M.; Bor, S.Öğe The effects of inhaler b-2 adrenergic agonists on esophageal high resolution manometry pressure metrics in asthma patients with inadequate symptom control(Wiley, 2015) Goksel, O.; Vardar, R.; Karakus, H. S.; Alev, Y.; Yildirim, E.; Erdinc, M.; Bor, S.Öğe Endoscopic view of intravascular platinum coil after embolization of bleeding duodenal ulcer: report of two cases(Georg Thieme Verlag Kg, 2009) Vardar, R.; Ozutemiz, O.; Parildar, M.Öğe Endoscopic view of intravascular platinum coil after embolization of bleeding duodenal ulcer: report of two cases(Georg Thieme Verlag Kg, 2009) Vardar, R.; Ozutemiz, O.; Parildar, M.Öğe Inter-observer agreement for diagnostic classification of esophageal motility disorders defined in high-resolution manometry(Oxford Univ Press Inc, 2015) Fox, M. R.; Pandolfino, J. E.; Sweis, R.; Sauter, M.; Abreu Y Abreu, A. T.; Anggiansah, A.; Bogte, A.; Bredenoord, A. J.; Dengler, W.; Elvevi, A.; Fruehauf, H.; Gellersen, S.; Ghosh, S.; Gyawali, C. P.; Heinrich, H.; Hemmink, M.; Jafari, J.; Kaufman, E.; Kessing, K.; Kwiatek, M.; Lubomyr, B.; Banasiuk, M.; Mion, F.; Perez-de-la-Serna, J.; Remes-Troche, J. M.; Rohof, W.; Roman, S.; Ruiz-de-Leon, A.; Tutuian, R.; Uscinowicz, M.; Valdovinos, M. A.; Vardar, R.; Velosa, M.; Wasko-Czopnik, D.; Weijenborg, P.; Wilshire, C.; Wright, J.; Zerbib, F.; Menne, D.High-resolution esophageal manometry (HRM) is a recent development used in the evaluation of esophageal function. Our aim was to assess the inter-observer agreement for diagnosis of esophageal motility disorders using this technology. Practitioners registered on the HRM Working Group website were invited to review and classify (i) 147 individual water swallows and (ii) 40 diagnostic studies comprising 10 swallows using a drop-down menu that followed the Chicago Classification system. Data were presented using a standardized format with pressure contours without a summary of HRM metrics. The sequence of swallows was fixed for each user but randomized between users to avoid sequence bias. Participants were blinded to other entries. (i) Individual swallows were assessed by 18 practitioners (13 institutions). Consensus agreement (<= 2/18 dissenters) was present for most cases of normal peristalsis and achalasia but not for cases of peristaltic dysmotility. (ii) Diagnostic studies were assessed by 36 practitioners (28 institutions). Overall inter-observer agreement was 'moderate' (kappa 0.51) being 'substantial' (kappa >0.7) for achalasia type I/II and no lower than 'fair-moderate' (kappa >0.34) for any diagnosis. Overall agreement was somewhat higher among those that had performed >400 studies (n = 9; kappa 0.55) and 'substantial' among experts involved in development of the Chicago Classification system (n = 4; kappa 0.66). This prospective, randomized, and blinded study reports an acceptable level of inter-observer agreement for HRM diagnoses across the full spectrum of esophageal motility disorders for a large group of clinicians working in a range of medical institutions. Suboptimal agreement for diagnosis of peristaltic motility disorders highlights contribution of objective HRM metrics.Öğe Novel esophageal speech therapy method in total laryngectomized patients: biofeedback by intraesophageal impedance(Oxford Univ Press Inc, 2016) Sahin, M.; Ogut, M. F.; Vardar, R.; Kirazli, T.; Engin, E. Z.; Bor, S.The loss of the best communication port after total laryngectomy surgery makes speech rehabilitation an important goal. Our aim was to improve the quality of esophageal speech (ES) using online esophageal multichannel intra-luminal impedance (MII) as a new biofeedback method. Twenty-six total laryngectomized patients were included. Before ES therapy, an esophageal motility test was carried out. MII catheters were placed in all subjects who were then randomized into two groups. Group 1 included 13 cases, who were retrained according to the classical method. Group 2 included 13 cases, who were retrained according to the simplified animation of air movements within the esophagus and upper stomach resulting from the modifications of intra-esophageal air kinetics gained by MII. The level of speech proficiency was evaluated relative to pretraining levels using perceptual scales in the third and sixth months. Acoustic voice was analyzed. The number of syllables read per minute and the intelligibility of monosyllabic and dissyllabic words were calculated. In this study, MII was used for the first time in alaryngeal speech rehabilitation as a biofeedback method; an overall sufficient speech level was achieved by 68.4% at the end of therapy, whereas attendance was 90%. A statistically significant improvement was found in both groups in terms of ES level compared with the pretraining period although there was no significant difference between groups. Although we did not observe the expected difference between groups suggested by our hypothesis, MII may be used as an objective tool to show patients how to swallow and regurgitate air during training, and may thus expedite ES theraphy both for the speech therapist and the patient in the future.Öğe THE PATTERN OF OESOPHAGEAL ACID EXPOSURE AND OESOPHAGEAL PRESSURE MORPHOLOGY IN PATIENTS WITH HIATUS HERNIA(B M J Publishing Group, 2011) Vardar, R.; Sweis, R.; Anggiansah, A.; Wong, T.Öğe PHARYNGEAL AND OESOPHAGEAL DYSMOTILITY AND DYSFUNCTION IN PATIENTS WITH CHRONIC COUGH: ASSESSMENT BY HIGH-RESOLUTION MANOMETRY(B M J Publishing Group, 2011) Vardar, R.; Sweis, R.; Anggiansah, A.; Wong, T.; Fox, M.Öğe Predictive value of esophageal motility test in the proficiency of esophageal speech(Oxford Univ Press Inc, 2015) Sahin, M.; Vardar, R.; Kirazli, T.; Ogut, F.; Akyildiz, S.; Bor, S.One method of speech rehabilitation following total laryngectomy surgery is esophageal speech therapy (EST). In this method, which has witnessed relatively low success rates at the end of therapy, identification of patients who can benefit from EST beforehand will be important for determining the appropriate method for alaryngeal speech rehabilitation and might be cost-effective, saving time and labor. To this end, this study conducted research on the feasibility of manometric data measured prior to therapy using an esophageal motility test (EMT) in order to determine the candidates most suitable for esophageal speech (ES) beforehand. A total of 51 total laryngectomy male patients who had never been subject to any kind of speech rehabilitation and had always been articulate were included in the study. Data were collected from 44 patients who completed EST, lasting for 6 months in total and consisting of 11 sessions. Manometric measures were obtained through EMT using a water-perfusion system with a Dent sleeve catheter on the patients prior to the therapy. Wepman's scale was used in order to evaluate ES proficiency. Following the therapy, in accordance with this scale, while patients whose scores was 1, 2, or 3 were considered as adequate, those whose scores were 4, 5, 6, or 7 were considered inadequate and were divided into two groups. Manometric correlations were analyzed between 17 patients (group I) who were able to perform ES at an adequate level and 27 patients (group II) who could not. No statistically significant difference between the groups could be observed in terms of average pressure generated within the upper and lower esophageal sphincters obtained through EMT, peak amplitude of esophageal body contraction pressure, contraction duration time, onset velocity, or peak velocity values. EMT conducted prior to application of EST to total laryngectomized patients did not have any value in determining the level of ES that a patient could reach. Our results also suggest that sphincter pressures or esophageal motility patterns do not have any predictive value and should not be performed.Öğe The role of Bernstein test with pH-impedance monitoring in different subtypes of GERD: Re-evaluation of an old technique(Lippincott Williams & Wilkins, 2013) Yapali, S.; Vardar, R.; Yildirim, E.; Bor, S.Öğe Should we abandon conventional manometric system in motility laboratories?(Wiley, 2015) Akpinar, Z.; Vardar, R.; Yuksel, E. Saritas; Unsal, B.; Yildirim, E.; Bor, S.Öğe Should we abandon conventional manometric system in motility laboratories?(Wiley, 2015) Akpinar, Z.; Vardar, R.; Yuksel, E. Saritas; Unsal, B.; Yildirim, E.; Bor, S.
