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Öğe Alkaloid profiling in Galanthus gracilis from Western Aegean by GC/MS(Georg Thieme Verlag Kg, 2015) Karakoyun, C.; Bozkurt, B.; Kaya, G., I; Onur, M. A.; Somer, N. U.Öğe Analysis of Amaryllidaceae alkaloids in Galanthus krasnovii by GC-MS(Georg Thieme Verlag Kg, 2015) Emir, A.; Emir, C.; Bozkurt, B.; Kaya, G., I; Eminagaoglu, O.; Onur, M. A.; Somer, N. U.Öğe Chemical characterization and biological activity of an endemic Amaryllidaceae species: Galanthus cilicicus(Elsevier Science Bv, 2017) Kaya, G. I.; Uzun, K.; Bozkurt, B.; Onur, M. A.; Somer, N. U.; Glatzel, D. K.; Fuerst, R.The phytochemical investigation on Galanthus cilicicus Baker (Amaryllidaceae) led to the isolation of four alkaloids (tazettine 1, galanthamine 2, sanguinine 3, and haemanthamine 4). The alkaloid patterns of bulbs and aerial parts of G. cilicicus were also studied by gas chromatography/mass spectrometry (GC/MS). Twenty alkaloids were detected. In the aerial parts, among the detected alkaloids, haemanthamine and tazettine were the main alkaloids, whereas in the bulbs galanthamine and tazettine were predominantly found. A microplate assay modified from in vitro Ellman's method was used to determine the acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory potentials of the alkaloidal extracts prepared from the bulbs and aerial parts of G. cilicicus. The prepared extracts showed remarkable AChE and BuChE inhibitory activities. Since some Amaryllidaceae alkaloids have been reported to exert anti-inflammatory properties, we have also investigated the potentials of both alkaloidal extracts to inhibit a key feature of inflammation, i.e. the interaction of leukocytes and endothelial cells. Both extracts concentration dependently decreased the adhesion of a humanmonocytic cell line onto tumor necrosis factor-alpha (TNF-alpha) activated primary human endothelial cells. Moreover, the extracts lowered the surface expression of the endothelial adhesion molecule (ICAM-1), which mediates leukocyteendothelial cell interaction. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved.Öğe GC-MS Investigation of Amaryllidaceae Alkaloids in Galanthus cilicicus(Georg Thieme Verlag Kg, 2015) Kayao, G., I; Uzun, K.; Bozkurt, B.; Onur, M. A.; Somer, N. U.Öğe Phytochemical constituents from Galanthus alpinus Sosn. var. alpinus and their anticholinesterase activities(Elsevier Science Bv, 2019) Emir, C.; Emir, A.; Bozkurt, B.; Somer, N. U.Phytochemical studies on Galanthus alpinus Sosn. var. alpinus from Turkey resulted in the isolation of 11 metabolites including, 1 terpenoid; (+)-blumenol A 1, 2 lignans; pinoresinol 2 and epipinoresinol 3, and 8 other compounds; (+)-homolycorine 4, (+)-8-O-demethylhomolycorine 5, arolycoricidine 6, N-Trans-feruloyltyramine 7, (-)-lycorine 8, nicotinic acid 9, O-methylnorbelladine 10 and hordenine 11. To the best of our knowledge, all compounds are reported for the first time from the title species. The chemical structures of the compounds were elucidated by MS, 1D and 2D experiments. Also, isolated compounds were subjected to in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity assays. (C) 2018 SAAB. Published by Elsevier B.V. All rights reserved.Öğe Phytochemical studies on Galanthus cilicicus(Georg Thieme Verlag Kg, 2014) Kaya, G., I; Uzun, K.; Sarikaya, B.; Onur, M. A.; Somer, N. U.Öğe Phytochemical studies on Galanthus gracilis L.(Georg Thieme Verlag Kg, 2015) Emir, C.; Emir, A.; Bozkurt, B.; Kaya, G.; Onur, M.; Somer, N. U.Öğe Quantitative determination of protopine in Hypecoum procumbens subsp atropunctatum(Georg Thieme Verlag Kg, 2015) Kaynar, E.; Emir, A.; Bozkurt, B.; Kayo, G., I; Onur, M. A.; Somer, N. U.