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Öğe Evaluation of 99mTc-Cefuroxime axetil for imaging of inflammation(Springer, 2007) Lambrecht, F. Yurt; Yilmaz, O.; Uenak, P.; Seyitoglu, B.; Durkan, K.; Baskan, H.Öğe Extraction, radiolabeling, and biodistribution of thebaine in rats(Springer Birkhauser, 2013) Enginar, H.; Unak, P.; Lambrecht, F. Yurt; Muftuler, F. Zumrut Biber; Seyitoglu, B.; Yurt, A.; Yolcular, S.; Medine, E. I.; Bulduk, I.The goal of this study was to determine the radiopharmaceutical potential of radioiodinated thebaine. Thebaine was extracted from dry capsules of opium poppy (Papaver somniferum L.), purified using high-performance liquid chromatography, and characterized with nuclear magnetic resonance and infrared spectroscopy. The purified thebaine was labeled with I-131 using the iodogen method. Normal and receptor-blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that the uptake of I-131-thebaine in the stomach, large intestine, spinal cord, and prostate was higher than in the other tissues. A greater uptake of radiolabeled thebaine in the rat brain was observed in the midbrain and hypothalamus. We concluded that (1) the labeling yield of I-131-thebaine was high, (2) a large amount of I-131-thebaine remained in the midbrain and hypothalamus, and (3) I-131-thebaine had enough stability for diagnostic scanning.Öğe Labeling of apigenin with I-131 and bioactivity of I-131-apigenin in male and female rats(Springer, 2009) Seyitoglu, B.; Lambrecht, F. Yurt; Durkan, K.Apigenin (4',5,7-trihydroxyflavone), one of the most common flavonoids, has been shown to possess a variety of biological activities including tumor growth inhibition and chemopreventation. In the present study, apigenin was labeled with I-131 using iodogen method and investigated of its bioactivity. Radiolabeling yield is 98 +/- 0.2%, as determined by radio thin layer chromatography (RTLC), electrophoresis and radio high performance liquid chromatography (RHPLC). Besides, structure analysis of synthesized cold iodoapigenin complex were assessed with LCMS/MS and H-1-NMR. Results of in vitro study indicated a high stability (3 hours) in human serum. Biodistrubition studies are performed in male and female albino Wistar rats. Biodistribution data related to the male rats showed significant uptake in the small intestine. The female rats biodistribution results indicated that the uptake of I-131-apigenin was high in the intestine and uterus.Öğe Radiolabeling of codeine with I-131 and its biodistribution in rats(Springer, 2009) Enginar, H.; Unak, P.; Lambrecht, F. Y.; Muftuler, F. Z. Biber; Medine, E. I.; Yolcular, S.; Yurt, A.; Seyitoglu, B.; Bulduk, I.Codeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with I-131 and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.Öğe Synthesis, radiolabeling and biodistribution of morphine glucuronide (mor-glu)(Springer, 2012) Enginar, H.; Unak, P.; Muftuler, F. Z. Biber; Lambrecht, F. Y.; Medine, E. I.; Yolcular, S.; Kilcar, A. Yurt; Seyitoglu, B.; Bulduk, I.The aim of this study was to synthesize a glucuronide conjugated morphine derivative which could be labeled with I-131, as a radiopharmaceutical, and to investigate its radiopharmaceutical potential using biodistribution studies in male Albino Wistar rats. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.). It was conjugated with UDP-glucuronic acid by using UDP-glucuronyl transferase (UDPGT) enzyme rich microsomes, purified by high performance liquid chromatography (HPLC) and characterized by nuclear magnetic resonance (NMR), infrared (IR) spectroscopy and liquid chromatography mass spectroscopy (LC-MS/MS). Normal and receptor blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that I-131 labeled morphine glucuronide (I-131-mor-glu) uptake in the small intestine, large intestine and urinary bladder was higher than in the other tissues of the rats in the blocked receptor and unblocked receptor. A greater uptake of the radio labeled substance was observed in the hypothalamus and mid brain than in the other branches of the rats' brains.