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Öğe Evaluation of the relationship between migraine disorder and oral comorbidities: multicenter randomized clinical trial(Tubitak Scientific & Technical Research Council Turkey, 2016) Peskersoy, Cem; Peker, Sule; Kaya, Aysegul; Unalp, Aycan; Gokay, NecmiBackground/aim: Although migraine is a common disorder, there is a lack of research investigating the possible relationship between migraine and oral health. The aim of the present study was to explore the relationship between temporomandibular disorders, bruxism, dental caries, periodontal status, and migraine disorder in a multicenter, parallel, case-controlled clinical study. Materials and methods: A total of 2001 participants were divided into two groups: migraineurs (nm = 998) and nonmigraineurs (nh = 1003). International Headache Society's Second Edition of International Classification of Headache Disorders and modified Migraine Disability Assessment surveys were administered to evaluate the level of migraine; a pretreatment questionnaire and the World Health Organization oral health assessment form were used to determine the oral comorbidities and their possible effects on DMFT index, gingival plaque index, existence of temporomandibular disorders, bruxism, and consistency of daily oral hygiene habits. Results: The mean age was 39.6 +/- 10.5 years. Female patients seemed to experience migraine attacks more than male patients (64%). The frequency of gastroesophageal reflux was higher in migraineurs in comparison with nonmigraineurs (47%) and tooth wear and abrasion also seemed more frequent (76%). DMFT and plaque index scores showed significant differences for both groups. Conclusion: There is a strong relationship between migraine and oral health status. The existence of reflux in addition to migraine leads to higher dental problems.Öğe Markers of long-term exposure to organophosphorus pesticides in farmers who work in viniculture and tobacco production in Turkey(Taylor & Francis Ltd, 2007) Soezmen, Buelent; Peker, Sule; Kaya, Uemmuehan; Erkan, Mualla; Soezmen, Eser YildirimThe first aim of this study was to evaluate the degree of organophosphorus ( OP) pesticides' exposure in viniculture and tobacco production workers via physical examination ( neurology and general health aspect) and analysis of paraoxonase ( PON1) and butyrylcholinesterase ( BuChE) activities. The second aim was to investigate if PON1 polymorphism plays any role in long-term OP exposure. A total of 93 farmers who work as applicators in agriculture were studied. The data were evaluated according to agricultural type, and although the total exposure time was similar in both areas, BuChE and PON1 activities of farmers who work in tobacco production were lower. Overall, BuChE and PON1 activities showed a depletion in the farmer group compared to age-matched controls. When the farmers were categorized according to the number of their symptoms, the BuChE activities of farmers who had two or more symptoms were found to be depleted ( n = 43, 2948 +/- 756) compared to farmers who had one or no symptoms ( n = 37, 3356 +/- 659). Allele frequencies of patients and controls for positions 55 and 192 were similar to Turkish population data and there was no association between the allele polymorphism and symptoms/signs of long-term exposure. Our results indicate that there is an important inhibition of PON1 activity in chronic OP poisoning, and this together with BuChE activity might well be used as a reliable index of chronic exposure to OP.