Yazar "Pekdemir, Fatih" seçeneğine göre listele

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    Anti-proliferative and Apoptotic Effects of Coordination Compounds of Zinc(II), Palladium(II), and Platinum(II) with Tridentate 4-(6-hydroxyphenyl)-2,6-di(thiazol-2-yl)pyridine
    (Wiley-V C H Verlag Gmbh, 2023) Pekdemir, Fatih; Sengul, Abdurrahman; Akgun, Oguzhan; Ari, Ferda; Acar-Selcuki, Nursel
    The mononuclear coordination compounds, [Zn(L)Cl-2] (1), [Pd(L)Cl]Cl (2), and [Pt(L)Cl]Cl (3) (L) is a tridentate-coordinated of 4-(6-hydroxyphenyl)-2,6-di(thiazol-2-yl)pyridine) were synthesized and characterized by different spectroscopic methods (FTIR, MALDI-TOF-MS, H-1 NMR, C-13 NMR, and UV/Vis). By using density functional theory (DFT) and time-dependent DFT (TD-DFT) methods, the geometrical parameters, UV/Vis absorption spectra, and infrared vibrational frequencies for the investigated compounds were explored. Anticancer activities of these compounds were determined by SRB viability assay in human lung (A549 and H1299), prostate (LNCAP), colorectal (HT-29), breast cancer (MDA-MB-231) and healthy bronchial (BEAS-2B), breast (MCF-10A), colon (CCD-18Co), and prostate (WPMY-1) epithelial cells. Caspase 3/7 activity, cleaved cytokeratin-18, and PARP levels were measured to determine apoptosis in the metal compounds found to be effective. Among the compounds, 1 showed a selective inhibiting effect and induced apoptosis on the cancer cells, thus further analyses are needed to evaluate its antitumor/anticancer activity.
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    Spectroscopic, electrochemical and electrocolorimetric properties of novel 2-(2 '-pyridyl)-1H-benzimidazole appended bay-substituted perylene diimide triads
    (Elsevier Science Sa, 2019) Pekdemir, Fatih; Orman, Efe Baturhan; Selcuki, Nursel Acar; Ozkaya, Ali Riza; Salih, Bekir; Sengul, Abdurrahman
    In this study, four new perylene diimide (PDI) derivatives incorporating 2-(2'-pyridyl)-1H-benzimidazole (2PBI) chromophores at the imide positions, in which 1 bearing non-bay-substituted perylene core, and those having four substituents at 1,6,7,12-bay positions of the perylene core, namely 2 bearing electron-withdrawing chlorine atoms, 3 bearing electron-donating 4-methoxyphenoxy groups and 4 bearing non-electron-donating 4-tert-butylphenoxy groups, respectively were synthesized and fully characterized by FT-IR, H-1 NMR, C-13 NMR, MALDI-TOF mass spectrometry and UV/Vis spectroscopy. The thermal properties were measured by thermogravimetric analysis (TGA) which showed that the materials (1-4) are thermally very stable (T-d > 450 degrees C). DFT was performed for geometry optimizations, and TDDFT was used to compare the calculated and the experimental UV/Vis electronic spectra at the B3LYP/6-311 G(d) level. Detailed measurements were carried out by the use of electroanalytical, spectroscopic and colorimetric techniques in order to understand redox natures, color changes and optoelectronic characters of the novel compounds. These 2PBI-functionalized PDI triads showed reversible reduction processes, chemically stable reduced species and considerably low HOMO-LUMO band gaps, as the new worthy members of photoactive charge transport materials for optoelectronic and photovoltaic systems. In addition, with distinct color changes associated with their redox processes in the solution, these new triads displayed great capacity for application in electrochromic devices. The emission maxima of the compounds were found to be red shifted in the solid state.
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    Spectroscopic, structural and DFT studies of luminescent Pt(II) and Ag(I) complexes with an asymmetric 2,2 '-bipyridine chelating ligand
    (Elsevier, 2021) Yilmaz, Ismail; Acar-Selcuki, Nursel; Coles, Simon J.; Pekdemir, Fatih; Sengul, Abdurrahman
    A new unsymmetrically substituted 2,2'-bipyridine ligand, 5-methyl-5'-carbomethoxy-2,2'-bipyridine (L) was isolated from the dry distillation of the copper(II) complex, mono-aqua-bis(trans-5-methyl-pyridine2-carboxylato- N,O)copper(II). the ligand was fully characterized. the spectroscopic and single-crystal Xray diffraction (SCXRD) studies of the coordination compounds of the ligand with platinum(II) and silver(I); cis-Pt(L)Cl-2 (1) and [Ag(L)(2)]PF6 (2), respectively are reported. in 1, the Pt centre coordinates to tertiary N atoms of the ligand and two chloride ions to form a neutral square-planar coordination sphere, while in 2, the Ag(I) centre is coordinated by two ligands through N atoms to generate a cationic flattened tetrahedron geometry in which two mean planes intersect each other at 50.93 degrees. the pyridine rings are nearly coplanar as revealed by the torsion angle of N2-C7-C6-N1 1.32(5)degrees. in both complexes, L acts as a chelating ligand through pyridyl N atoms. in 1, the molecular units are stacked in a head-to-tail fashion with a Pt center dot center dot center dot Pt separation of 3.5 degrees A. Supramolecular self-assembly of the molecular units by extensive intermolecular contacts through C-H center dot center dot center dot Cl and C-H center dot center dot center dot O between the adjacent units results in an infinite two-dimensional flattened-out herringbone structure in the crystalline state. in 2, the molecular units are interconnected with each other by C-H center dot center dot center dot O contacts between the adjacent units running parallel to each other. Both complexes are fluorescent in solution and have emission maxima in the UV-Vis regions, which is a very important property for optoelectronic applications. DFT (density functional theory) and TD-DFT (time-dependent-DFT) calculations were performed at B3LYP/6-311+G(d,p)/LANL2DZ level to explore structural, electronic, and spectroscopic properties to compare with the experimental results. the molecular orbitals (MOs) were carried out with DFT at the same level. (C) 2020 Elsevier B.V. All rights reserved.