Yazar "Nart, D" seçeneğine göre listele
Listeleniyor 1 - 20 / 35
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe 100 consecutive adult to adult right lobe living donor liver transplantation.(Blackwell Munksgaard, 2004) Kucuk, HF; Cag, MM; Unsal, G; Icoz, G; Nart, D; Karasu, Z; Zeytunlu, M; Kilic, M; Yuzer, Y; Tokat, YÖğe Adult and pediatric living donor liver transplantation for acute liver failure.(John Wiley & Sons Inc, 2006) Kilic, M; Aydin, U; Kirdok, O; Aydogdu, S; Karasu, Z; Akyildiz, M; Yilmaz, F; Nart, D; Tumgor, G; Tamsel, S; Zeytunlu, MÖğe Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease(Elsevier Science Bv, 2004) Ozbaran, M; Omay, SB; Nalbantgil, S; Kultursay, H; Kumanlioglu, K; Nart, D; Pektok, EObjective: Ischemic heart disease accounts for 50% of all cardiovascular deaths and is the leading cause of congestive heart failure. Medical therapy, cardiac assist devices and surgical procedures including heart transplantation have limited efficiency and availability. Stem cell transplantation represents a new therapeutic opportunity for such patients. Method: Six patients with the diagnosis of ischemic cardiomyopathy were included in this study. All of the patients had clinical, radiological and echocardiographic signs of heart failure, and reduced left ventricular ejection fraction (LVEF less than or equal to25%). They underwent coronary angiography and stress tests with dobutamine echocardiography, thallium scintigraphy and positron emission tomography to assess myocardial ischemia and viability. Peripheral stem cells were mobilized and collected by apheresis. They were transplanted into areas of injury with open-heart surgery. To increase blood flow to the engrafted areas, coronary artery by-pass surgery was also performed. Results: The patients were followed at least for 4 months. Echocardiography, thallium scintigraphy and positron emission tomography were repeated after at least 6 weeks following surgery. There was a significant increase in life quality and NYHA class. Some benefit was documented on echocardiography, thallium scintigraphy, and positron emission tomography. Conclusion: This approach opens a new window in the treatment of 'no hope' patients with congestive heart failure. (C) 2003 Elsevier B.V. All rights reserved.Öğe Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease.(Amer Soc Hematology, 2003) Omay, SB; Ozbaran, M; Nalbantgil, S; Kultursay, H; Kumanlioglu, K; Nart, D; Pektok, EÖğe Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart disease.(Amer Soc Hematology, 2003) Omay, SB; Ozbaran, M; Nalbantgil, S; Kultursay, H; Kumanlioglu, K; Nart, D; Pektok, EÖğe Biochemical and radiologic predictors of hepatic steatosis in living liver donors(W B Saunders Co, 2003) Karasu, Z; Kilic, M; Orguc, S; Nart, D; Kobat, A; Akarca, U; Aydogdu, S; Demirbas, T; Akyildiz, M; Arikan, C; Tokat, YÖğe Biochemical and radiologic predictors of hepatic steatosis in living liver donors(W B Saunders Co, 2003) Karasu, Z; Kilic, M; Orguc, S; Nart, D; Kobat, A; Akarca, U; Aydogdu, S; Demirbas, T; Akyildiz, M; Arikan, C; Tokat, YÖğe The effect of atorvastatin on lipid peroxidation and plaque formation in hypercholesterolemic atherosclerosis model(Elsevier Sci Ireland Ltd, 2004) Sezer, ED; Sozmen, EY; Nart, D; Onat, TÖğe Effect of intratumoral and peritumoral vascular and lymphatic invasions on prognosis of operated non small cell lung cancer patients(Elsevier Ireland Ltd, 2005) Turhan, K; Cagirici, U; Goksel, T; Cakan, A; Samancilar, O; Nart, D; Aktin, BÖğe Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia(Soc General Microbiology, 2003) Yalaz, M; Hilmioglu, S; Metin, D; Akisu, M; Nart, D; Cetin, H; Ozturk, C; Isik, E; Kultursay, NSpecies of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. stricturn. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. stricturn in the brain, liver and heart.Öğe Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia(Soc General Microbiology, 2003) Yalaz, M; Hilmioglu, S; Metin, D; Akisu, M; Nart, D; Cetin, H; Ozturk, C; Isik, E; Kultursay, NSpecies of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. stricturn. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. stricturn in the brain, liver and heart.Öğe Fatty infiltration is the best histological predictor for treatment response in chronic hepatitis(Elsevier Science Bv, 2003) Akarca, US; Nart, D; Gunsar, F; Karasu, Z; Ersoz, G; Yuce, G; Batur, YÖğe Fatty infiltration is the best histological predictor for treatment response in chronic hepatitis(Elsevier Science Bv, 2003) Akarca, US; Nart, D; Gunsar, F; Karasu, Z; Ersoz, G; Yuce, G; Batur, YÖğe Functional reversal of factor V Leiden mutation following liver transplantation in a patient with Budd-Chiari syndrome(W B Saunders Co, 2003) Karasu, Z; Kilic, M; Killi, R; Celebi, A; Nart, D; Akdeniz, M; Tokat, YÖğe Functional reversal of factor V Leiden mutation following liver transplantation in a patient with Budd-Chiari syndrome(W B Saunders Co, 2003) Karasu, Z; Kilic, M; Killi, R; Celebi, A; Nart, D; Akdeniz, M; Tokat, YÖğe Hepatocellular carcinoma in children and effect of living-donor liver transplantation on outcome(Wiley, 2006) Arikan, C; Kilic, M; Nart, D; Ozgenc, F; Ozkan, T; Tokat, Y; Yagci, RV; Aydogdu, SHepatocellular carcinoma (HCC) is primarily observed in the older children and in most cases it develops in association with liver cirrhosis. Liver transplantation offers a good chance for long-term cure. To evaluate the outcome of children with HCC and the impact of living-donor orthotopic liver transplantation (OLT) on survival a retrospective review of radiographic, laboratory, pathologic, and therapeutic data in 13 children (six female and seven male) with chronic liver disease accompanied with HCC were studied. The patients were divided into two groups according to therapeutic modality: transplanted and non-transplanted patients. Kaplan-Meier survival curves in various therapeutic groups were plotted. The mean age of patients was 6.4 +/- 4.8 yr. Pediatric end-stage liver disease score was adapted to model for end-stage liver disease score for HCC and ranged between 1-44 and 18-44, respectively. The underlying liver diseases were tyrosinemia type 1 (n = 6), chronic hepatitis B infection (n equals;6), glycogen storage disease type 1 (n = 1). Alfa-feto protein levels were elevated in all patients except one. Median number of tumor nodules was three (1-10), median maximal diameter of tumor nodules was 3.4 cm (0.5-8). Eleven patients were eligible for OLT whereas two patients were not eligible. Seven of the 11 patients considered for transplantation underwent living-donor OLT. Remaining four patients died while waiting on cadaveric transplant list. Overall 1 and 4-yr survival rates for all patients were 53.3 and 26.6%, respectively, and were found significantly higher in transplanted children than non-transplanted children (72%, 72% vs. 33% and 16.6%). No patient had tumor recurrence at median of 36-month follow-up after OLT. OLT is a life-saving procedure for children with chronic liver disease accompanying with HCC. Living-donor OLT avoids the risk of tumor progression and transplant ineligibility in these children.Öğe Hepatocellular carcinoma in liver transplant era: A clinicopathologic analysis(Elsevier Science Inc, 2003) Nart, D; Arikan, C; Akyildiz, M; Yuce, G; Demirpolat, G; Zeytunlu, M; Karasu, Z; Aydogdu, S; Killi, R; Yuzer, Y; Tokat, Y; Kilic, MHepatocellular carcinoma (HCC) is one of the most common tumors in the world, and the prognosis is usually poor. Today, liver transplantation (LT) is a radical but frequently curative treatment modality for HCC. In selected patients, it cures HCC and the underlying cirrhosis at the same time. The present clinicopathological study examined the importance of tumor characteristics for their effects on recurrence and survival rates after LT for HCC. Forty-two native hepatectomy specimens among 250 consecutive orthotopic liver transplantations contained HCC. Patients were predominantly men (30 men, 12 women), ranging in age from 1 to 61 years (median 51). While 20 patients received cadaveric organs, 22 were transplanted from living donors. In 14 patients (33%) HCC presented as a solitary nodule, 5 (12%) as two nodules; 2 (5%) as three nodules; and 21 patients (50%) as more than three nodules. The maximal diameter of the largest tumor not larger than 3 cm in 28 patients (66%), exceeding this size in 14 patients (34%). There was a significant correlation between nodule number and tumor size (r = 0.36, P = 0.05). While 23 patients had no sign of vascular involvement, 17 tumors showed microscopic invasion and two large vessel involvement. There was a positive correlation between vascular invasion and nodule number (r = 0.41, P = 0.05). The histopathological grade of differentiation of the tumors was assessed as "well" in seven patients (14%), moderate in 28 (72%), and poor in 7 (14%). The differentiation was significantly poorer when vascular invasion was observed (r = 0.43, P = .01). According to the TNM classification, 11 patients (26%) were stage I, 6 (14%) stage II, 13 (31%) stage III, and 12 (29%) stage IV. After a median follow-up of 10 months (1-50 months), the overall mortality was 18% (n = 8). Patient survival at 6 month, 1, and 4 years was 88%, 80%, and 60%, respectively. The outcome was significantly poorer for TNM stage IV versus stage I, II, and III tumors to (P = .02). Tumor recurred in three patients at 4,6, and 50 months after liver transplantation. The sites of recurrence were bone, lung, and adrenal glands. In conclusion, liver transplantation represents a safe and feasible treatment for hepatocellular carcinoma with excellent outcomes compared with other treatment modalities. Liver transplantation offers excellent survival rates and chance for cure in stages I, II, and III hepatocellular carcinoma in cirrhotic patients.Öğe Hepatocellular carcinoma in liver transplant era: A clinicopathologic analysis(Elsevier Science Inc, 2003) Nart, D; Arikan, C; Akyildiz, M; Yuce, G; Demirpolat, G; Zeytunlu, M; Karasu, Z; Aydogdu, S; Killi, R; Yuzer, Y; Tokat, Y; Kilic, MHepatocellular carcinoma (HCC) is one of the most common tumors in the world, and the prognosis is usually poor. Today, liver transplantation (LT) is a radical but frequently curative treatment modality for HCC. In selected patients, it cures HCC and the underlying cirrhosis at the same time. The present clinicopathological study examined the importance of tumor characteristics for their effects on recurrence and survival rates after LT for HCC. Forty-two native hepatectomy specimens among 250 consecutive orthotopic liver transplantations contained HCC. Patients were predominantly men (30 men, 12 women), ranging in age from 1 to 61 years (median 51). While 20 patients received cadaveric organs, 22 were transplanted from living donors. In 14 patients (33%) HCC presented as a solitary nodule, 5 (12%) as two nodules; 2 (5%) as three nodules; and 21 patients (50%) as more than three nodules. The maximal diameter of the largest tumor not larger than 3 cm in 28 patients (66%), exceeding this size in 14 patients (34%). There was a significant correlation between nodule number and tumor size (r = 0.36, P = 0.05). While 23 patients had no sign of vascular involvement, 17 tumors showed microscopic invasion and two large vessel involvement. There was a positive correlation between vascular invasion and nodule number (r = 0.41, P = 0.05). The histopathological grade of differentiation of the tumors was assessed as "well" in seven patients (14%), moderate in 28 (72%), and poor in 7 (14%). The differentiation was significantly poorer when vascular invasion was observed (r = 0.43, P = .01). According to the TNM classification, 11 patients (26%) were stage I, 6 (14%) stage II, 13 (31%) stage III, and 12 (29%) stage IV. After a median follow-up of 10 months (1-50 months), the overall mortality was 18% (n = 8). Patient survival at 6 month, 1, and 4 years was 88%, 80%, and 60%, respectively. The outcome was significantly poorer for TNM stage IV versus stage I, II, and III tumors to (P = .02). Tumor recurred in three patients at 4,6, and 50 months after liver transplantation. The sites of recurrence were bone, lung, and adrenal glands. In conclusion, liver transplantation represents a safe and feasible treatment for hepatocellular carcinoma with excellent outcomes compared with other treatment modalities. Liver transplantation offers excellent survival rates and chance for cure in stages I, II, and III hepatocellular carcinoma in cirrhotic patients.Öğe Infliximab: A new therapeutic agent in acute pancreatitis?(Lippincott Williams & Wilkins, 2004) Oruc, N; Ozutemiz, AO; Yukselen, V; Nart, D; Celik, HA; Yuce, G; Batur, YPurpose: Tumor necrosis factor alpha (TNF-alpha) has a central role in the pathogenesis of acute pancreatitis and related systemic complications. The aim of this study is to investigate the therapeutic effectiveness of monoclonal TNF antibody (infliximab) in acute edematous and severe necrotizing pancreatitis models in rats. Methods: One hundred rats were randomly divided into 10 groups. Acute edematous pancreatitis (AEP) was induced by injection of cerulein 20 mug/kg 4 times subcutaneously at hourly intervals. Severe necrotizing pancreatitis (SNP) was induced by retrograde injection of 3% taurocholate into the common biliopancreatic duct. Infliximab 8 mg/kg was given via intravenous infusion. Serum amylase activity, pancreatic histopathology, myeloperoxidase enzyme activity (MPO), and pulmonary changes were assessed. Results: Infliximab treatment significantly decreased serum amylase activity (11939+/-1914 U/L versus 3458+/-915 U/L, P<0.001) and histopathologic score (4.1 +/- 0.5 versus 1.5 +/- 0.3, P<0.001) in AEP. It also suppressed neutrophil infiltration and MPO activity of the pancreatic tissue. In SNP, infliximab treatment was found to decrease pathologic score (9.4+/-1.2 versus 3.6+/-0.8, P<0.001) and serum amylase activity (20442 +/- 2375 versus 8990 +/- 1730, P<0.01). It ameliorated both parenchymal and fatty tissue necrosis of the pancreas. Infliximab also alleviated alveolar edema and acute respiratory distress syndrome like pulmonary complications, but the difference was not significant. Conclusions: Chimeric TNF antibody, infliximab, should be evaluated for treatment of acute pancreatitis.Öğe Liver failure in transplanted liver due to Amanita falloides(Elsevier Science Inc, 2005) Kucuk, HF; Karasu, Z; Kilic, M; Nart, DTwo patients underwent liver transplantation due to Amanita falloides poisoning. In one of them the clinical symptoms, signs, and laboratory findings related to liver failure were similar to the findings before the transplantation. The patient died and the pathological examination of the liver was similar to the patient's earlier explanted liver.