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Öğe Multicenter Survey of Endoscopic Treatment of Vesicoureteral Reflux Using Polyacrylate-Polyalcohol Bulking Copolymer (Vantris)(Elsevier Science Inc, 2014) Kocherov, Stanislav; Ulman, Ibrahim; Nikolaev, Sergey; Corbetta, Juan Pablo; Rudin, Yuriy; Slavkovic, Andjelka; Dokumcu, Zafer; Avanoglu, Ali; Menovshchikova, Ludmila; Kovarskiy, Semen; Skliarova, Tatiana; Weller, Santiago; Bortagaray, Juan I.; Lopez, Juan C.; Duran, Victor; Burek, Carol; Sager, Cristian; Dmitriy, Maruhnenko; Garmanova, Tatiana; Djamal, Aliev; Jovanovic, Zorica; Vacic, Nikola; Abu Arafeh, Wael; Chertin, BorisOBJECTIVE To evaluate an outcome of endoscopic correction of vesicoureteral reflux (VUR) using Vantris (Promedon, Cordoba, Argentina) in terms of its effectiveness and morbidity in a multicenter study. MATERIALS AND METHODS From 2009 to 2013, 611 patients (210 boys and 401 girls) with a mean age of 3.56 years (range, 1 month-18 years) were treated at 7 centers worldwide endoscopically with Vantris injection. VUR was unilateral in 413 and bilateral in 198 patients comprising 809 renal refluxing units (RRUs). Of these, primary VUR was present in 674 RRUs (83.3%) and 135 (16.7%) were complex cases. Reflux was grades I-V in 24 (2.96%), 123 (15.2%), 451 (55.8%), 158 (19.5%), and 53 (6.6%) RRUs respectively. The follow-up continued from 6 to 54 months. RESULTS Reflux resolved in 759 RRUs (93.8%) after first Vantris injection, in 26 (3.1%) after second, and in 6 (0.7%) after third injection, respectively. VUR improved to grade I after 1 or 2 injections in 5 ureters (0.6%), which needed no further treatment. Thirteen ureters (1.6%) failed endoscopic correction and required ureteral reimplantation. Vesicoureteral junction obstruction requiring ureteral reimplantation developed in 6 ureters (0.7%) and in 4 (0.5%) required stent insertion. Twenty-three patients (3.8%) suffered afebrile urinary tract infection. Seven (1.2%) developed febrile urinary tract infection. None of the studied patients demonstrated VUR recurrence on voiding cystourethrography. CONCLUSION The results of this multicenter survey confirm that endoscopic subureteral Vantris injection is a simple, safe, and effective outpatient procedure for treating all grades of VUR. (C) 2014 Elsevier Inc.