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Öğe The ability of Ga-67 scintigraphy to detect the lesions of Echinococcus multilocularis infection: Preliminary results(Springer, 2006) Inceboz, T.; Mavi, A.; Kaya, G. Capa; Korkmaz, M.; Goktay, Y.; Yilmaz, O.; Uner, A.; Durak, H.Aim: To assess the ability of Ga-67 scintigraphy to detect the lesions of Echinococcus multilocularis (EM) infection. Materials and Methods: An animal model of EM infection was developed. The infected tissues taken from stock infection were placed into the abdominal cavity of uninfected animals operatively. The success of implantation was controlled 20-25 days after implantation. Five infected and 2 healthy animals were studied. All of the animals were examined by ultrasound before the scintigraphic evaluation. After the injection of 7.4 MBq (200 mu Ci)Ga-67 citrate intravenously, static images from the whole anterior thorax and abdomen were obtained at 24, 48 and 72 hours. Visual and semiquantitative analyses were performed. In semiquantitative analysis, an irregular region of interest was drawn over the thorax as the background, excluding the heart and a second region of interest was drawn over the abdomen, excluding the liver and spleen. Abdomen/background ratios were calculated using the mean counts. Results: In the visual evaluation, it was noticed that there was considerably increased Ga-67 uptake in the abdomens of the infected animals. In infected animals, mean abdomen/background ratios at 48 and 72 hours (3.76 +/- 1.04, 4.13 +/- 0.72, respectively) were increased compared with mean abdomen/background ratios at 24 hours (2.94 +/- 0.77). These increases in abdomen/background ratios were statistically significant at 72 hours (p=0.04). Between the infected animals and control group, mean abdomen/background ratios were compared, and statistically significant differences were found in the images obtained at 48 and 72 hours. Conclusion: Imaging at 72 hours seems to be more suitable imaging time for the diagnosis of alveolar echinococcosis. Ga-67 scintigraphy may successfully demonstrate the lesions of EM infection localized intraperitoneally. The method of Ga-67 scintigraphy is useful because it is simple, non-invasive and relatively safe.Öğe Alveolar hydatid disease: Imaging findings and surgical approach(Acta Medical Belgica, 2007) Parsak, C. K.; Demiryurek, H. H.; Inal, M.; Sakman, G.; Koltas, I. S.; Erkocak, E. U.; Korkmaz, M.; Acarturk, T. . O.Purpose : We report six cases of Alveolar Hydatid Disease (five in the liver and one in the gastrosplenic ligament invading the spleen) in which curative resection of the liver (five cases) and splenectomy (one case) were performed. Material and Methods : The records of the six patients with AHD were retrospectively evaluated. Demographics of the patients, symptoms, laboratory findings, including serology were recorded. Imaging studies determined the extent of the disease preoperatively. Classification of the lesions was done according to the PNM (P = parasitic mass in the liver. N = involvement of neighbouring organs, and M = metastasis) staging system designed by the World Health Organization. All the surgical procedures were performed as complete resections, where negative margins were approved by frozen sections. Chemotherapy with albendazole (10 mg/kg/day) was continued postoperatively for two years in five of the six patients who were alive. Results : All of the cases were from East Anatolia of Turkey, which is an endemic region. The mean age was 39.6 years (15-54 years). Major complications occurred post-operatively in all patients, possibly due to the extensive resection. No recurrence was seen during the 5 year follow-up of two cases and 2 year follow-up of three cases. Conclusion : The treatment of Alveolar Hydatid Disease is curative radical resection. Thus, pre-operative Imaging studies to determine the extent and stage of the disease are of crucial importance.Öğe Autoantibodies in Patients with Fasciolosis(Iranian Scientific Society Medical Entomology, 2009) Kaya, S.; Demirci, M.; Cetin, E. Sesli; Aridogan, B. Cicioglu; Sahin, M.; Korkmaz, M.Background: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. Methods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2. Anti-liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. Results: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7,7,4,2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. Conclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure.Öğe Autoantibodies in Patients with Fasciolosis(Iranian Scientific Society Medical Entomology, 2009) Kaya, S.; Demirci, M.; Cetin, E. Sesli; Aridogan, B. Cicioglu; Sahin, M.; Korkmaz, M.Background: Antiself humoral immune responses have been detected not only in classical autoimmune diseases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic diseases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some antibodies related to hepatobiliary systems, in patients with fasciolosis. Methods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2. Anti-liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. Results: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7,7,4,2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was detected for any of the autoantibodies' frequency between patients with fasciolosis and control group. However, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically significant higher than controls. Conclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactivity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship between fasciolosis and autoimmunity is still obscure.Öğe Case report: A rarely seen cause of brain abscess - neurotoxocariasis(Elsevier Sci Ltd, 2014) Sipahi, O. R.; Kivrak, E. Erdem; Korkmaz, M.; Tasbakan, M.; Pullukcu, H.; Arda, B.; Yamazhan, T.; Ulusoy, S.Öğe THE EFFECTIVENESS OF THE LOWER DOSE OF LASER TREATMENT ON KNEE OSTEOARTHRITIS(Bmj Publishing Group, 2017) Ekiz, E.; Capaci, K.; Korkmaz, M.Öğe Emerging and Re-Emerging Parasitic Infections of the Central Nervous System (CNS) in Europe(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Tunali, V.; Korkmaz, M.In a rapidly evolving global landscape characterized by increased international travel, migration, and ecological shifts, this study sheds light on the emergence of protozoal and helminthic infections targeting the central nervous system (CNS) within Europe. Despite being traditionally associated with tropical regions, these infections are progressively becoming more prevalent in non-endemic areas. By scrutinizing the inherent risks, potential outcomes, and attendant challenges, this study underscores the intricate interplay between diagnostic limitations, susceptibility of specific population subsets, and the profound influence of climate fluctuations. The contemporary interconnectedness of societies serves as a conduit for introducing and establishing these infections, warranting comprehensive assessment. This study emphasizes the pivotal role of heightened clinician vigilance, judicious public health interventions, and synergistic research collaborations to mitigate the potential consequences of these infections. Though rare, their profound impact on morbidity and mortality underscores the collective urgency required to safeguard the neurological well-being of the European populace. Through this multifaceted approach, Europe can effectively navigate the complex terrain posed with these emergent infections. © 2023 by the authors.Öğe Endovascular management of congenital arteriovenous fistulae in the neck(Elsevier Masson, 2016) Guneyli, S.; Cinar, C.; Bozkaya, H.; Korkmaz, M.; Oran, I.Purpose: The purpose of this study was to evaluate congenital arteriovenous fistulae in the neck, including vertebrovertebral and carotico-jugular arteriovenous fistula, with their endovascular management. Materials and methods: Six patients with congenital arteriovenous fistulae in the neck who underwent endovascular treatment between March 2001 and December 2013 at the Department of Radiology, Ege University School of Medicine were enrolled into this retrospective study. There were four men and two women, with a mean age of 8.6 (range 4-17) years. Patients' demographics and symptoms were noted. Diagnostic computed tomography and/or magnetic resonance angiography were available in all patients. Parent artery and vein of the arteriovenous fistula, location of the fistula, the other features of fistula, endovascular occlusion site, number and type of endovascular materials, and length of follow-up were reviewed. Results: Four patients had vertebrovertebral fistula, while two patients had carotido-jugular fistula (fistula between maxillary artery and external jugular vein). Four patients underwent detachable balloon occlusion together with coil embolization, while two patients underwent detachable balloon occlusion only. The parent artery was occluded in five patients without clinical consequences, and the remaining fistula was occluded with preservation of the parent artery. The patients did not have any complication in the follow-up period (mean follow-up, 9 months). Conclusion: Congenital arteriovenous fistulae in the neck are extremely rare. Endovascular fistula occlusion with parent vessel sacrifice appears to be a safe and minimally invasive treatment option with good results during the follow-up period. (C) 2015 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe EPIGALLOCATECHIN-3-GALLATE TRIGGERS AUTOPHAGY MEDIATED CELL DEATH VIA UP-REGULATION OF TMEM74 GENE EXPRESSION IN CHRONIC MYELOID LEUKEMIA CELLS(Pergamon-Elsevier Science Ltd, 2014) Goker, B.; Caliskan, C.; Mutlu, Z.; Tepedelen, B. Erbaykent; Korkmaz, M.; Saydam, G.; Gunduz, C.; Avci, C. BirayÖğe Parasitic myositis due to Toxocara spp. infection(Pergamon-Elsevier Science Ltd, 2017) Ekmekci, O.; Kavasoglu, G.; Argin, M.; Babaoglu, A.; Karasoy, H.; Korkmaz, M.Öğe Rare but intriguing lesions of gastrointestinal tract: Parasitic infestations(Springer, 2014) Pehlivanoglu, B.; Doganavsargil, B.; Sezak, M.; Korkmaz, M.Öğe Seroepidemiological Investigation of Toxocariasis in the Isparta Region of Turkey(Iranian Scientific Society Medical Entomology, 2010) Demirci, M.; Kaya, S.; Cetin, E. S.; Aridogan, B. C.; Onal, S.; Korkmaz, M.Background: Toxocariasis is a common disease around the world. Our objective was to determine Toxocara seroprevalence in humans in the city of Isparta, Southwest Turkey, in respect of some determinants such as age, socio-economic level, residence in city center or rural area etc. Methods: Five hundred and thirty four individual participants from Isparta center and 85 from Asagi Gokdere village were included in the study. T. cati specific antibodies were analyzed using excretory-secretory (ES)-enzyme-linked immunosorbent assay (ELISA) method. Results: T. cati antibodies were detected as positive in 73 (13.6%) of 534 samples which were collected from subjects living in the city center and 24 (28.2%) of 85 samples from Asagi Gokdere village. Toxocara seropositivity was detected among 15.6% of whole study group. The seroprevalence of toxocariasis was significantly higher among subjects from village than in subjects from city center (P=0.001). While gender, high school education, source of the water which is used, family income and geophagia/eating nail behaviors were the features which were detected as being associated with toxocariasis seropositivity (odds ratios=0.5; 6.52; 3.61; 0.43; 0.13 respectively), owning dogs or cats and hand washing were detected as being not associated with toxocariasis seropositivity (P > 0.05). Furthermore, Toxocara seropositivity was significantly higher among subjects in 0-10 than >40 year-old group (P=0.02). Conclusion: It can be suggested that untreated lost pet population, environmental contamination, and way of life have influence on the epidemiology of toxocariasis.Öğe The short-and long-term effectiveness of transcatheter arterial embolization in patients with intractable hematuria(Elsevier Masson, 2016) Korkmaz, M.; Sanal, B.; Aras, B.; Bozkaya, H.; Cinar, C.; Guneyli, S.; Gok, M.; Adam, G.; Duzgun, F.; Oran, I.Purpose: Selective transarterial embolization (TAE) of the internal iliac artery is a well-known alternative technique to control intractable bladder hemorrhage (IBH). We explored the shortand long-term effectiveness of, and clinical outcomes after, TAE in patients with IBH. Materials and methods: In this retrospective study, we reviewed the hospital records of 18 IBH patients non-responsive to conservative medications who underwent TAE between January 2003 and May 2014. The early-and long-term effectiveness of TAE was investigated in the context of hematuria control, complications, mortality, requirement for blood transfusions, and hematocrit level. Results: Sixteen of the 18 patients underwent endovascular treatment; the technical success rate was 88%. TAE allowed complete remission in 16 patients (100% clinical success). On follow-up, mean hematocrit (P = 0.003) and hemoglobin (P = 0.005) levels significantly improved. Thirteen of the 16 patients (81%) required no further emergency admission after TAE during a mean follow-up period of 18.1 months (range, 3-105 months). Conclusion: TAE is a feasible, effective, and safe technique in both the short-and long-term for the treatment of IBH. (C) 2015 Editions francaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.Öğe Vector-borne parasitic infections after the earthquake(CSIRO, 2023) Zeyrek, F.Y.; Yakut, S.; Korkmaz, M.The transmission of vector-borne infections after an earthquake is related to the changes in the environment caused by the earthquake. The displacement of thousands of people, especially in areas where vector-borne diseases are endemic, can significantly increase human exposure to mosquitoes and other vectors and the pathogens they may carry in overcrowded environments and inappropriate temporary shelters, leading to an increase in human infection cases. The devastating earthquakes in Türkiye on 6 February 2023 pose a risk of the spread and outbreaks of vector-borne infections such as cutaneous leishmaniasis (CL) and malaria, which are endemic in the region. Public health authorities should prioritise surveillance in all earthquake-affected areas. Immediate detection and identification of local vector species, monitor environmental conditions and potential breeding grounds, insecticide application and use of mosquito nets and development of interventions to prevent the emergence of vector-borne infections are essential. Case diagnosis and treatment follow-up, prophylaxis, training of the public and health personnel, improving temporary shelter conditions and facilitating access to clean drinking water and health services are essential to minimise the impact of vector-borne infections in post-earthquake situations. © 2023 CSIRO. All rights reserved.