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Öğe Adult Intracranial Ependymal Tumors: Results of TROD Neurooncology Group 07-009 Study(Elsevier Ireland Ltd, 2022) Arslan, S. Aytac; Guney, Y.; Erpolat, P.; Kamer, S.; Ercis, E.; Tezcan, Y.; Akgun, Z.[No Abstract Available]Öğe Anaplastic Ependymoma: Experience of Three Centers in Western Part of Turkey(Wiley, 2019) Ataseven, E.; Onen, S.; Kizmazoglu, D.; Demirag, B.; Bolat, E.; Kamer, S.; Kantar, M.[No abstract available]Öğe CAN TEMOZOLOMIDE EXTEND SURVIVAL OF DIFFUSE INTRINSIC BRAINSTEM GLIOMAS?(Elsevier Ireland Ltd, 2010) Kamer, S.; Mutluer, S.; Anacak, Y.; Kantar, M.; Cetingul, N.; Ersahin, Y.Öğe Childhood Hodgkin Lymphoma: Single Center Experience(Wiley, 2017) Ataseven, E.; Sivis, Z.; Malbora, B.; Belen, F. B.; Gunes, B.; Kamer, S.; Anacak, Y.; Atabay, B.; Turker, M.; Oniz, H.Öğe Clinical Features, Prognostic Factors and Outcome of Children with Ewing Sarcoma: A Single-center Experience(Galenos Publishing House, 2023) Al, I.O.; Demirağ, B.; Sabah, D.; Kamer, S.; Avşargil, B.D.; Argın, M.; Oymak, Y.Introduction: Ewing sarcoma (ES) is a rare, aggressive, malignant tumor. It is the second most common malignant bone tumor in children. A total of 20-25% of patients are metastatic at the time of diagnosis. The survival rate for localized disease (LD) is approximately 70-74%. For metastatic disease (MD), it is about 30%. The most important prognostic factor affecting survival is the presence of MD at diagnosis. In this study, we investigated the clinical characteristics, treatment outcome, and factors affecting the prognosis and survival of patients followed up with the diagnosis of ES. Materials and Methods: Between 2007 and 2020, a total of 24 ES patients aged 0-18 years were retrospectively analyzed. Results: The most common complaint was pain and swelling in the lesion area (n=9), followed by pain (n=5), swelling (n=3), abdominal pain (n=2), shortness of breath (n=2), facial paralysis (n=1), spinal compression findings (leg pain and walking difficulty) (n=1) and hematuria (n=1). ES was bone-derived in 19 patients (79%). Of these, 14 had LD and 5 had MD at the time of diagnosis. Extraskeletal Ewing sarcomas (EES), was detected in five patients (21%) and derived from the kidney (n=1), rectus abdominis (n=1), left quadriceps femoris muscle (n=1), left upper thoracic region and lumbar region paraspinal muscles (n=2). The rate of MD was 25% (6/24) in the entire patient group. Disease progression was observed in three patients during treatment. Relapse at follow-up was observed in 6 of 19 patients in complete remission. The median time to relapse was 20 months (minimum 13, maximum 34 months) from diagnosis. The median survival of our patients after relapse was 14.5 months (minimum 6-maximum 27 months). Radiological response and histopathological response to induction therapy, presence of relapse or progression, and relapse site were found to be correlated with survival (Fisher’s Exact test p=0.02, 0.0047, <0.001, 0.001 respectiveley). Conclusion: ES is a cancer with high mortality and morbidity. Although the most common symptoms are pain and swelling, the symptoms may vary depending on the region from which the tumor originates. Response to induction therapy and the presence of relapse-progression are factors affecting prognosis. Treatment should be personalized to improve survival. © 2023, Galenos Publishing House. All rights reserved.Öğe DEMOGRAPHICAL AND EPIDEMIOLOGICAL FEATURES OF 5970 ADULT CASES EVALUATED THROUGH THE EGE NEURO-ONCOLOGY BOARD (EGE NORO-ONKOLOJI KONSEYI, ENOK) BETWEEN 1996-2013(Oxford Univ Press Inc, 2014) Ozgiray, E.; Durusoy, R.; Yurtseven, T.; Cagli, S.; Dalbasti, T.; Oner, K.; Ovul, I.; Kamer, S.; Oktar, N.Öğe Determining the Patterns of Care to Adolescent and Young Adult Cancer Patients in Turkey: Turkish Oncology Group Study(Elsevier Science Inc, 2020) Sert, F.; Kamer, S.; Guney, Y. Yukselen[No abstract available]Öğe Development of an Intensity Modulated Total Skin Electron Irradiation Technique(Elsevier Science Inc, 2020) Koylu, M.; Kamer, S.; Anacak, Y.; Yalman, D.[No abstract available]Öğe Does the Timing of Radiotherapy Impact Survival of Glioblastoma Multiforme Patients?(Elsevier Science Inc, 2011) Tezcanli, E. K.; Ucuncu, A.; Sarihan, S.; Aksu, A.; Eroglu, C.; Alco, G.; Kamer, S.; Ekenel, M.; Arslan, S. Aytac; Abacioglu, U.Öğe The effect of the ATM inhibitor AZD0156 on the radiosensitivity of human breast cancer and lung fibroblast cells(NLM (Medline), 2023) Yilmaz, U.; Kamer, D.; Asik, A.; Kara, H.G.; Gündüz, C.; Kamer, S.Aims: To evaluate the effect of the combination of irradiation and AZD0156 on apoptosis, cell cycle progression, and clonogenic survival in human breast cancer and fibroblast cells. Methods and Material: Estrogen receptor-positive breast cancer cell line MCF-7 and healthy lung fibroblast cell line WI-38 were obtained. Following employing proliferation analysis, cytotoxicity analysis was done to calculate the IC50 values of AZD0156 in MCF-7 and WI-38 cell lines. Following the application of AZD0156 and irradiation, flow cytometry analysis was performed for evaluating cell cycle distribution and the extent of apoptosis. Plating efficiency and surviving fraction were calculated for the clonogenic assay. Statistical Analysis Used: SPSS Statistics for Windows, Version 17.0. (SPSS Inc. Chicago) and GraphPad Prism Version 6.0 for Windows (GraphPad Software, San Diego, California USA) softwares were used to analyze data. Results: AZD0156 and irradiation dose of 2-10 Gy had no effect on apoptosis on MCF-7 cells. The combination treatment of AZD0156 and 2 Gy, 4 Gy, 6 Gy, 8 Gy, and 10 Gy irradiation induced G0/G1 phase arrest by 1.79, 1.79, 1.50, 1.25, and 1.52-fold compared to the control group, respectively on MCF-7 cell lines. Combination treatment of AZD0156 and each different irradiation dose affected clonogenic survival owing to increased radiosensitivity (p: 0.02). AZD0156 and irradiation dose of 2 Gy, 4 Gy, 6 Gy, 8 Gy, and 10 Gy decreased the cell viability rate of WI-38 cells by 1.05, 1.18, 1.22, 1.04, and 1.05-fold compared to the control group, respectively. No efficacy was detected on cell cycle analysis, and clonogenic survival was not significantly decreased in WI-38 cells. Conclusion: The combination use of irradiation and AZD0156 has improved efficacy of tumor cell-specific cell cycle arrest and decreasing clonogenic survival.Öğe Effect of Tumor Treating Fields and Radiotherapy Combination on Brain Tumor and Normal Brain Cell Lines(Elsevier Science Inc, 2020) Yalman, D.; Koylu, M.; Kayabasi, C.; Kamer, S.; Ozkan, E.; Yelken, B. Ozmen; Gunduz, C.[No abstract available]Öğe Evaluation of acute and late radiation morbidity in patients with gynaecologic malignancy using the RTOG criteria and Franco-Italian glossary(I R O G Canada, Inc, 2008) Yildirim, G.; Ozsaran, Z.; Yalman, D.; Kamer, S.; Aras, A.Purpose: The purpose of this study was to evaluate acute and late radiation morbidity in patients with gynaecologic malignancy using the RTOG criteria and Franco-Italian glossary, and to compare the usefulness and disadvantages of each system. Materials and Methods: Between February 2001 and February 2003, 107 patients with gynaecologic malignancy who received either radical or adjuvant external radiotherapy intracavitary brachytherapy or radiochemotherapy were enrolled in this study. The patients were evaluated before radiotherapy and weekly during radiotherapy for acute morbidity using the RTOG grading system and Franco-Italian glossary. Postradiotherapy evaluation was done one month after radiotherapy and at 3-month intervals thereafter. Median follow-up duration was 17 months. Morbidity was graded and recorded according to each scoring system. Results: Median age was 46 years (range 37-82). Sixty-four patients (59.8%) had endometrial cancer. Radical radiotherapy was applied to 26 patients because of inoperability and 81 patients received postoperative radiotherapy. Biologically effective doses for the bladder, rectum and vagina were 98.39, 103.54 and 121.81, respectively, for late morbidity (BED3); 70.88, 72.84 and 80.92, respectively, for acute morbidity (BED,,). According to the RTOG grading system acute morbidity rate for the genitourinary and gastrointestinal systems, and skin were 52.3%, 83.2% and 63.5%, respectively. Late morbidity rate for the bladder, colon-rectum, skin and vagina were 16.8%, 20.6%, 47.7% and 51.4%, respectively. The morbidity rate for the bladder, nonspecific abdominal, hematopoietic system, uterus-vulva-vagina, skin and rectum were 35.4%, 29.9%, 5.6%, 60.8%, 40.1 % and 32.7%, respectively using the Franco-Italian glossary. In patients with carcinoma of the vulva - whose treatment fields were wider - acute morbidity rate according to RTOG criteria was higher (p = 0.057); photon energy (6 My rather than 1.25 MV) (p = 0.01) and treatment interruption of more than eight days (p = 0.019) were correlated with decreased long-term morbidity. According to the Franco-Italian glossary morbidity rates were higher in patients who received chemotherapy (p = 0.047), both external radiotherapy and brachytherapy (p = 0.022) and treatment interruption of less than eight days (p = 0.019). Conclusion: There is no common language between the RTOG grading system and Franco-Italian glossary for defining and scoring radiation morbidity. Up to date no standard and well-defined system has been developed for recording and reporting acute and late radiation morbidity in gynaecologic malignancy, but rather it depends on the subjective evaluation and experience of a radiation oncologist and subjective complaints of the patient, and sometimes on clinical findings. A standard and well-defined user friendly objective scoring system is needed to define and predict the morbidity rate more properly.Öğe Evaluation of anxiety level during intracavitary brachytherapy applications in patients with gynecologic malignancy(Pergamon-Elsevier Science Ltd, 2005) Yalman, D.; Kamer, S.; Ozsaran, Z.; Celik, O.; Bolukbasi, Y.; Bildilk, O.; Haydaroglu, A.Öğe Evaluation of anxiety levels during intracavitary brachytherapy applications in women with gynecological malignancies(I R O G Canada, Inc, 2007) Kamer, S.; Ozsaran, Z.; Celik, O.; Bildik, O.; Yalman, D.; Bolukbasi, Y.; Haydaroglu, A.Purpose: To evaluate the anxiety levels of women treated for gynecological malignancies using intracavitary brachytherapy. Methods: Anxiety levels prior to and after intracavitary brachytherapy application and factors influencing anxiety levels were evaluated. Women were evaluated for quality of life and psychological status before each brachytherapy application using the Hospital Anxiety and Depression Scale (HADS). Scores were grouped as follows: 0-7 = normal, 8-10 = borderline, 11-21 = abnormal. Women were also questioned about other factors which could affect anxiety levels such as marital status, education level, number of pregnancies and prior surgical history. Results: Between January 2003 and August 2004, 146 women with a median age of 56 years were evaluated (range: 27-80). Eighty-six women had cervix uteri carcinoma and 63 had endometrial carcinoma. Sixty-seven women were premenopausal and 85 women were postmenopausal. The median pregnancy number was three (range = 0-10). Eighty-nine women had at least three children. Sixty-seven women had had previous operations. One hundred and twenty-five women were married and 24 women were unmarried or widowed. Before treatment, the anxiety scores were scored as normal in 49 (32%), borderline in 41 (28%), and abnormal in 59 (40%). Anxiety levels were lower in 69 women during the last application as compared with the pretreatment levels (p = 0.00). Marital status and pregnancy number showed a significant correlation with anxiety scores (p = 0.04). Age, level of education or having had a previous operation showed no significant correlation with anxiety level. Conclusion: These results indicate that intracavitary brachytherapy is associated with anxiety. Women need to be given detailed information before the brachytherapy application to reduce anxiety. Additional studies are needed to determine it.Öğe Granulocytic Sarcomas in Children Can Present Like Solid Tumors; Experience of EGE University from Turkey(Wiley-Blackwell, 2016) Ozdemir, H. Hekimci; Cetingul, N.; Akinci, B.; Ozdemir, O.; Kantar, M.; Aksoylar, S.; Hekimgil, M.; Ozsan, N.; Kamer, S.; Anacak, Y.; Kansoy, S.Öğe HEALTH STATUS EVALUATION OF CHILDREN WITH BRAIN TUMORS WHO WERE TREATED BY CRANIOSPINAL IRRADIATION(Elsevier Ireland Ltd, 2011) Sengul, A.; Kamer, S.; Anacak, Y.Öğe High Dose Rate (HDR) Brachytherapy in Childhood Rhabdomyosarcomas: Experience of a Single Center(Wiley, 2017) Kamer, S.; Celik, A.; Avanoglu, A.; Ergun, O.; Palamar, M.; Yagci, A.; Kadioglu, B.; Cetingul, N.; Kantar, M.; Turhan, T.; Anacak, Y.Öğe Intraoperative extracorporeal irradiation and re-implantation of involved bone for the treatment of musculoskeletal tumors(Biomed Central Ltd, 2007) Anacak, Y.; Sabah, D.; Demirci, S.; Kamer, S.The purpose of this trial is to evaluate the results of musculoskeletal tumors which is treated with limb salvage surgery and extracorporeal radiotherapy. Patients were treated with en-bloc resection followed by 50 Gy single dose extracorporeal irradiation and re-implantation of involved bone segments. Nine of fifteen were female and 6 were male, median age was 19. Tumor originated from tibia in 7 patients, femur in 3, humerus in 3, calcaneus in I and scapula in 1. Preoperative chemotherapy was given to 12 patients, 3 of them had not been treated previously. Median follow-up time of the survivors was 22 months (range 2-47 months); local recurrence and lung metastases occurred in one patient (local recurrence was away from the re-implanted bone segment), and lung metastases were reported in another 3 patients. Wound healing problems occurred in 4 patients and delayed union in 2 patients. Amputation was performed in 2 patients due to uncontrolled infection, and infected bone was replaced by a fibula graft in another patient. Treatment was successful in 12 patients where functional results were good in 9, excellent in 2 and not evaluated in 1. Limb salvage using en-bloc resection followed by intraoperative extracorporeal irradiation and re-implantation of involved bone is a useful and cheap reconstruction method in appropriately selected patients.Öğe INVESTIGATING THE EFFECTS OF RADIATION FRACTION DOSES ON THE MOLECULAR BARRIER PERMEABILITY OF AN IN VITRO BLOOD-BRAIN BARRIER MODEL(Oxford Univ Press Inc, 2024) Ozturk, M.; Caglar, F.; Koylu, M.; Kamer, S.[Abstract Not Available]Öğe Investigation of Molecular Sub-Groups by Immunohistochemical Methods and its Prognostic Importance in Medulloblastoma(Wiley, 2021) Ataseven, E.; Kantar, M.; Aktas, S.; Erol, A.; Gokbayrak, O.; Ertan, Y.; Kamer, S.[No Abstract Available]
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