Yazar "Cetingul, Nazan" seçeneğine göre listele
Listeleniyor 1 - 20 / 27
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe ASSESSMENT OF SCHOOL-RELATED PROBLEMS OF CHILDHOOD CANCER PATIENTS: A STUDY FROM WEST OF TURKEY(Wiley Periodicals, Inc, 2012) Yilmaz, Medine; Sari, Hatice Yildirim; Kantar, Mehmet; Aksoylar, Serap; Cetingul, Nazan; Erermis, SerpilÖğe Bone mineral density in survivors of childhood acute lymphoblastic Leukemia and risk factors(Karger, 2008) Goksen, Damla; Aksoylar, Serap; Ozen, Samim; Demirag, Bengu; Cetingul, Nazan; Darcan, SukranÖğe Cutaneous Side Effects of Chemotherapy in Pediatric Oncology Patients(Quadrant Healthcom Inc, 2015) Ceylan, Can; Kantar, Mehmet; Tuna, Arzu; Ertam, Ilgen; Aksoylar, Serap; Gunaydin, Asli; Cetingul, NazanÖğe Cytoprotective effect of amifostine in the treatment of childhood malignancies(Wiley-Liss, 2007) Midvat, Levent; Cetingul, Nazan; Kantar, Mehmet; Demirao, Bengu; Aksoylar, Serap; Kansoy, SavapÖğe Determination of School-Related Problems in Children Treated for Cancer(Sage Publications Inc, 2014) Yilmaz, Medine C.; Sari, Hatice Yildirim; Cetingul, Nazan; Kantar, Mehmet; Erermis, Serpil; Aksoylar, SerapThis descriptive and case-control study was carried out in a pediatric oncology outpatient clinic to determine the school-related physical, social, and psychological problems and problems experienced in academic achievement of children treated for cancer. The sample of the study consisted of 56 Turkish patients with cancer, aged 7-18 years, who were in remission and attending school as well as their parents, a control group of patients who did not have cancer, and their teachers. A Child Information Form, a Child Health Questionnaire Parent's Form of 50 questions, a Behavior Evaluation Scale for Children, and Young People and a Teacher's Report Form were used as data collection tools in the study. Of the children, 30.3% experienced various physical difficulties stemming from cancer therapy that affected their school life. The number of late enrollments, the number of children repeating a grade, and the rates of school absenteeism were also found to be higher in the survivors than in the controls.Öğe DIFFUSE PONTINE GLIOMAS OF THE CHILDHOOD: DOES TEMOZOLOMIDE IMPROVE SURVIVAL?(Wiley Periodicals, Inc, 2012) Anacak, Yavuz; Oniz, Haldun; Kantar, Mehmet; Kadioglu, Bengu; Kara, Gulsen; Kamer, Serra; Vergin, Canan; Cetingul, NazanÖğe Enteral nutrition is feasible in pediatric stem cell transplantation patients(Wiley Periodicals, Inc, 2012) Bicakli, Derya Hopanci; Yilmaz, Medine C.; Aksoylar, Serap; Kantar, Mehmet; Cetingul, Nazan; Kansoy, SavasWe aimed to demonstrate whether enteral nutrition (EN) is feasible in daily practice of hematopoietic stem cell transplantation (HSCT).Nutritional records of 100 patients were evaluated. Patients with poor oral intake were fed by EN with tube. A total of 79 patients required nutritional support. Of them, 71 were fed by EN only. Five were fed by EN plus parenteral nutrition (PN),three were fed by PN only. Median duration of EN was 21 days. In the EN only group, 68% gained or maintained their weight. EN should be considered as a feasible option for nutrition support in children undergoing HSCT. Pediatr Blood Cancer 2012; 59: 13271329. (C) 2012 Wiley Periodicals, Inc.Öğe EVALUATION OF CISPLATINUM OTOTOXICITY AND ITS EFFECT ON QUALITY OF LIFE IN LONG-TERM SURVIVORS(Wiley Periodicals, Inc, 2012) Kantar, Mehmet; Polat, Doga Ceren; Bilgen, Cem; Aksoylar, Serap; Kirazli, Tayfun; Cetingul, Nazan; Kansoy, SavasÖğe Evaluation of Long Term Respiratory Complications in Childhood and Adolescent Cancer Survivors(Galenos Publ House, 2023) Ergin, Firat; Cetingul, Nazan; Demir, Esen; Sayiner, Abdullah; Alper, Hudaver; Gulen, FigenAim: In addition to increased survival rates, systemic complications which can impair the quality of life have been seen in 25-30% of childhood and adolescent cancer cases. The respiratory system is one of the severely affected systems. We aimed to evaluate late respiratory complications and risk factors in pediatric and adolescent cancers.Materials and Methods: We examined the pulmonary complications of 50 cancer patients and 40 control cases. We asked about environmental exposures, physical examinations performed, and pulmonary function tests (PFT) spirometry, diffusing capacity of the lungs for carbon). X-ray was performed on all patients in the patient group and on patients with indications in the control group.Results: In the patient group, there was impairment of pulmonary function in 52%, [24% small airway disease (SAD)], 14% diffusion disorders (DD) and 14% combined disorders (CD) compared to 22.5% in the control group (p=0.007). There was a higher risk of restrictive disorder and/ or SAD in those cancer patients who were diagnosed prior to 2 years of age. Additionally, there was a higher rate of SAD in those patients with soft tissue sarcomas and a higher rate of restrictive disease in those patients who had received high-dose alkylating agents. No significant PFT impairment was observed in the other patient groups.Conclusion: There is a high incidence of respiratory impairment in childhood and adolescent cancer survivors. They need to be followed up by a multidisciplinary team and be informed about the additional risk factors which may cause lung function loss.Öğe Experiences of Parents With the Physical Care Needs at Home of Children With Cancer: A Qualitative Study(Lippincott Williams & Wilkins, 2013) Sari, Hatice Yildirim; Yilmaz, Medine; Ozsoy, Suheyla; Kantar, Mehmet; Cetingul, NazanBackground: Between cancer treatment courses, children who have not developed any complications or neutropenia are sent home until the start of the next treatment protocol. Objective: The aim of this study was to describe the experiences of parents in the home care of children who had been recently diagnosed with cancer and were undergoing cancer treatment but had been discharged from the hospital between treatment protocols. Methods: The study was carried out at Ege University, Turkey. Twelve parents of 12 children between 0 and 18 years of age participated in an in-depth interview. The data were analyzed according to Orem's Self-care Deficit Theory. Results: The main themes were basic conditioning factors, self-care agency, and self-care needs. Some parents changed their place of residence because of the cancer treatment, focused on the recovery of the child, and experienced fear, perception difficulties, and difficulties related to self-care needs. Conclusions: Parents report difficulties with extreme emotions and dilemmas in maintaining their daily routines of life secondary to fear of infection and challenges with feeding their children. Implications for Nursing: A well-planned discharge education, home visits, and telephone consultation interventions are essential to meet the needs of children and their parents who are at home between treatment courses.Öğe F-18-FDG PET/CT in pediatric lymphoma: Comparison of the Deauville criteria with semiquantitative analysis and CT in interim and post-treatment nodal evaluation(Kuwait Medical Assoc, 2019) Avci, Neslihan Cetin; Burak, Zeynep; Oral, Aylin; Cetingul, NazanObjectives: To investigate and compare the role of visual assessment according to the Deauville Criteria (DC) and semiquantitative assessment by maximum standardized uptake value (SUVmax) and CT, in interim and post-therapy "F-FDG PET/CT scans in the nodal involvement of pediatric lymphoma. Design: Retrospective study Setting: Training and Research Hospital Subjects: Forty-nine PET/CT scans (15 interim, 34 post-therapy) of 30 pediatric patients [19Hodgkin Lymphoma (HL) / 11 non-Hodgkin Lymphoma (NHL)] were retrospectively reviewed. Unenhanced low-dose CT component of PET/CT were compared with data derived from DC and SUVmax and all were correlated with radiologic, pathological, laboratory records and clinical follow-up. Main outcome measures: SUVmax, DC scores and CT findings in interim and/or post-therapy PET/CT scan Results: in 15 interim PET/CT scans, 23 and 12 nodal disease sites were detected by CT and PET (with SUVmax and DC), respectively. in 34 post-therapy scans, 36 regions were detected by CT and metabolic assessment revealed 31 regions. in HL, specificity to predict therapy response was 77.7% and 64.4% for interim evaluation and 95.1% and 75.8% for post-therapy evaluation by metabolic assessment methods and CT, respectively. Negative predictive value (NPV) was 100% for each interim and post-therapy evaluation method. Sensitivity was 100% for post-therapy metabolic evaluation and CT. in NHL, specificity to predict therapy response was 100% and 28.5% for interim evaluation and 75% and 62.5% for post-therapy evaluation by metabolic assessment methods and CT, respectively. NPV was 100% for each interim evaluation method, 42.8% for post-therapy metabolic evaluation, 26.3% for post-therapy CT; sensitivity was 75% for post-therapy metabolic evaluation and 56.2% for post-therapy CT. Conclusions: Our study demonstrated that the assessment according to DC and SUVmax showed concordant results and could be safely used both in interim and post-therapy PET/CT scans of pediatric patients with lymphoma. Even if metabolic evaluation is superior to CT, these methodologies are complementary to each other, and one should review them both synchronously.Öğe FREQUENCY OF METABOLIC SYNDROME AND THE ROLE OF RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA WHO COMPLETED THERAPY(Wiley-Liss, 2010) Oymak, Yesim; Turedi, Aysen; Yaman, Yontem; Buyukinan, Muammer; Ozek, Gulcihan; Cetingul, Nazan; Vergin, CananÖğe Langerhans Cell Histiocytosis: Excellent Local Control with Low Dose Radiotherapy(Akad Doktorlar Yayinevi, 2019) Kamer, Serra Arun; Kirakli, Esra Korkmaz; Cetingul, Nazan; Kantar, Mehmet; Saydam, Güray; Anacak, YavuzLangerhans cell histiocytosis (LCH) is a rare disorder. Uncontrolled clonal proliferation of langerhans cells leads to a diversity of clinical manifestations. Low dose Radiotherapy (RT) is used mainly for osseous manifestations as a sole treatment or in combination with surgery/chemotherapy/steroids. Altough the mechanism of action of RT is an unresolved issue, it's usually used in adjuvant/palliative settings, also as first-line local therapy with curative intent in unresectable or resectable cases in case surgery would result in functional compromise. This study is conducted to review indications, dose-fractionation schedules, clinical characteristics and outcomes of LCH patients received local RT mainly for osseous lesions. The medical records of biopsy proven all LCH patients referred to our center and treated with RT between 2000-2016 were evaluated retrospectively. Disease-free survival (DFS), local control and side effects were defined as study end-points. There was 35 patients, 21 of them were children. At presentation 65.7% had single system-single bone, 20% had single system-multiple bone, 15% had multisystem disease.Soft tissue extension were detected in 16 children, 4 adults (p= 0.013). Mean radiation dose was 10.8 Gy. Median follow-up from the date of biopsy was 105 months (range= 8-204) in children and 88 (range:31-245) in adults (log rank p:0.029).Complete response rate was 97%. 11 children and 1 adult experienced relapse (p= 0.05), median interval for relapse was 9months in children, 19months in adults. The most common relapse pattern was as single system-multiple bone (58.3%). Local control was 97.1%. Median disease free survival was 85 months. Low dose local RT seems to be effective and safe in multidisciplinary management of LCH.Öğe Leukemogenesis as a new approach to investigate the correlation between up regulated gene 4/upregulator of cell proliferation (URG4/URGCP) and signal transduction genes in leukemia(Springer, 2013) Dodurga, Yavuz; Oymak, Yesim; Gunduz, Cumhur; Satiroglu-Tufan, N. Lale; Vergin, Canan; Cetingul, Nazan; Avci, Cigir Biray; Topcuoglu, NejatThe aim of the study is to the determine the profiles of cell cycle genes and a new candidate oncogene of URG4/URGCP which play role in leukemia, establishing the association between the early prognosis of cancer and the quantitation of genetic changes, and bringing a molecular approach to definite diagnosis. In this study, 36 newly diagnosed patients' with ALL-AML in the range of 0-18 years and six control group patients' bone marrow samples were included. Total RNA was isolated from samples and then complementary DNA synthesis was performed. The obtained cDNAs have been installed 96 well plates after prepared appropriate mixtures and assessed with LightCycler(A (R)) 480 Real-Time PCR quantitatively. CHEK1, URG4/URGCP, CCNG1, CCNC, CDC16, KRAS, CDKN2D genes in the T-ALL group; CCND2, ATM, CDK8, CHEK1, TP53, CHEK2, CCNG2, CDK4, CDKN2A, E2F4, CCNC, KRAS genes in the precursor B-ALL group and CCND2, CDK6 genes in the AML group have shown significant increase in mRNA expression level. In the featured role of acute leukemia the regulating signaling pathways of leukemogenesis partially defined, although identification of new genetic markers in acute leukemia subgroups, will allow the development of early diagnostic and new treatment protocols.Öğe Management of Childhood Thyroid Nodules: Surgical and Endocrinological Findings in a Large Group of Cases(Galenos Yayincilik, 2017) Divarci, Emre; Celtik, Ulgen; Dokumcu, Zafer; Ergun, Orkan; Ozok, Geylani; Ozen, Samim; Simsek, Damla Goksen; Darcan, Sukran; Cetingul, Nazan; Oral, Aylin; Ertan, Yesim; Demirag, Bengu; Celik, AhmetObjective: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred pediatric cases. Methods: A retrospective analysis of patients admitted with a thyroid nodule between 2006 and 2014 was performed. Detailed ultrasonography and fine-needle aspiration biopsy (FNAB) were the cornerstones of the diagnostic approach. Results: One hundred-three children (72 female, 31 male) with a mean age of 13.1 +/- 3.6 years (3-18 years) were admitted to our center. Management strategy was surgery in 58 patients and follow-up in 45 patients. Mean nodule size was 17 +/- 12.7 mm (2-45 mm). The diagnoses were listed as benign solitary nodule (48 patients), thyroid carcinoma (26 patients), multinodular goiter (23 patients), Hashimoto thyroiditis (4 patients), and Graves' disease (2 patients). Surgical procedures were nodulectomy/lobectomy (32 patients), total thyroidectomy (TT) (13 patients), or TT+ neck dissection (13 patients). The rate of malignancy was 25% in the total group and 44% in the surgery group. The malignancy rate was higher in patients younger than 12 years compared to older children (41% vs. 17%, p = 0.040). Metastasis was seen in 38% of the malignant nodules. Postoperative complications were transient hypocalcemia (8%), permanent hypocalcemia (1.7%), and unilateral vocal cord paralysis (1.7%). Recurrence or mortality was not encountered in the 5.4 +/- 1.2-year follow-up period. Conclusion: Thyroid nodule in a child requires an aggressive diagnostic approach due to increased risk of malignancy and metastasis. Intraoperative frozen section examination must be done as a useful adjunct to determine the surgical strategy. Incidence of complications is small in thyroid surgery when performed by experienced surgeons.Öğe Medulloblastoma: Clinicopathologic evaluation of 51 cases.(Springer, 2007) Ertan, Yesim; Sezak, Murat; Demirag, Bengu; Kantar, Mehmet; Cetingul, Nazan; Ersahin, Yusuf; Mutluer, Saffet; Akalin, TanerÖğe Melanotic progonoma of the skull in infancy(Springer, 2008) Kantar, Mehmet; Sezak, Murat; Turhan, Tuncer; Kitis, Omer; Mutluer, Saffet; Demirag, Bengu K.; Aksoylar, Serap; Akalin, Taner; Ersahin, Yusuf; Cetingul, NazanIntroduction Melanotic progonoma or melanotic neuroectodermal tumor is a rare tumor in infancy. This lesion has to be considered in the differential diagnosis of benign or malignant lesions of calvarium. Case report The authors present a case of a 4-month-old infant with left retroauricular mass. The patient had a subcutaneous mass that is fixed to the underlying skull. CT and MRI scans showed left occipitotemporal expansile mass. The tumor was removed by surgery. A tumor, brownish-black in color, was diagnosed as melanotic progonoma. The patient remained symptom-free for the last 2 years after complete surgery. Discussion Extracranial subcutaneous masses involving the skull are uncommon in infants. Benign or malignant lesions may occur as lumps on calvarium. Physical examination and some laboratory findings are helpful in the assessment of patient. Benign or malignant lesions can be differentiated by craniography, CT, or MRI scans, but exact diagnosis of melanotic progonoma is made by histopathology and immunostaining, as was in the presented case. Cranial vault progonomas have a better outcome by complete surgery. The tumors usually do not recur in long-term period.Öğe Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma(Taylor & Francis Ltd, 2009) Kantar, Mehmet; Kosova, Buket; Cetingul, Nazan; Gumus, Sevinc; Toroslu, Ertug; Zafer, Nur; Topcuoglu, Nejat; Aksoylar, Serap; Cinar, Mehtap; Tetik, Asli; Eroglu, ZuhalThis study aimed to investigate the association of the methylenetetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphisms with serum drug levels and toxicities after high-dose methotrexate (MTX) infusion. The study included 37 children with acute lymphoblastic leukemia or non-Hodgkin lymphoma. Serum MTX levels and toxicities of bone marrow, liver and kidney were analysed. Genotype analysis of the C677T and A1298C gene polymorphisms from genomic DNA of the subjects was performed by real-time PCR. Subjects with MTHFR polymorphism for C677T (CT, TT) had significantly higher MTX levels at 24h (p=0.009), and these genotypes did not seem to cause toxicity. Subjects with MTHFR polymorphism for A1298C (AC, CC) had significantly higher MTX levels at 48h (p=0.02), and had more grade III/IV anemia (p=0.02), thrombocytopenia (p=0.0001), elevated AST levels (p=0.04) and frequent febrile neutropenic episodes (p=0.004). The present study suggests that A1298C gene, but not C677T polymorphism is associated with MTX-related toxicity.Öğe Monoclonal antibody therapy for CD-20 positive non-Hodgkin lymphoma: EGE university experience(Wiley-Liss, 2007) Demirag, Benu; Cetingul, Nazan; Kantar, Mehmet; Aksoylar, Serap; soy, Savas Kan; Hekimgil, MineÖğe Mucocutaneous findings in pediatric patients with bone marrow transplantation(Turkish Soc Dermatology Venerology, 2017) Aksoylar, Serap; Ceylan, Can; Gunaydin, Asli; Ertam, Ilgen; Kantar, Mehmet; Tuna, Arzu; Cetingul, Nazan; Kansoy, SavasBackground and Design: Bone marrow transplantation (BMT) is performed for many malign and non-malign diseases in pediatric patients. Cutaneous signs in transplant patients are usually encountered in the presence of underlying primary diseases or due to the intense conditioning regimens that include chemotherapy and radiotherapy protocols. In this study, it is aimed to define mucocutaneous changes in pediatric patients with BMT. Materials and Methods: A total of 44 patients, in whom BMT was planned between 2010 and 2011, were included in the study. Dermatological examinations were performed at the beginning of the study and were repeated once a week in the first month, once a month in the following 5 months; and once in every 3 months in the last 1.5 years of follow-up. Results: Forty-one patients were completed the study. The mean age of 41 patients was 9.24 years (range: 1-17 years). Of the subjects, 26 (64%) were male and 15 (36%) were female. Dermatological signs, in order of frequency, were mucositis (75.6%), xeroderma (70.7%), alopecia (46.3%), nail disorders (24.3%), inflammatory skin diseases (24.2%), aphthous stomatitis (22%), cutaneous hyperpigmentation (22%), graft versus host diseases (17.1%), infectious diseases (15.5%), and maculopapular rash (4.8%). Conclusion: Dermatological diseases can be frequently observed in BMT patients. Close monitoring of dermatological signs is important to minimize the complications of the treatment in this patient group.