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Öğe COMPARISONS OF INVASIVE AND NON-INVASIVE CARDIAC OUTPUT MEASURMENT METHODS IN PULMONARY HYPERTENSION(Elsevier Science Inc, 2017) Simsek, Evrim; Demir, Emre; Kayikcioglu, Meral; Nalbantgil, Sanem; Huseynov, Rashad; Mogolkoc, Nesrin; Can, Levent; Kultursay, HakanÖğe Effects of thrice weekly nocturnal hemodialysis on arterial stiffness(Elsevier Ireland Ltd, 2012) Demirci, Meltem Sezis; Celik, Gulperi; Ozkahya, Mehmet; Tumuklu, Murat; Toz, Huseyin; Asci, Gulay; Duman, Soner; Basci, Ali; Kircelli, Fatih; Ozdogan, Oner; Demirci, Cenk; Can, Levent; Isik, Ismet Onder; Ok, ErcanObjective: In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. Methods: Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h thrice weekly conventional HD (CHD) were followed for one year. Radial-carotid pulse wave velocity, augmentation index and echocardiography were performed at baseline and 12th month. Results: Mean age of the patients was 49 +/- 11 years, 30.8% were female, 27.5% had diabetes mellitus and mean dialysis vintage was 57 +/- 47 months. Baseline demographical, clinical and laboratory parameters were similar between groups. During a mean follow-up of 15.0 +/- 0.1 months, blood pressure remained similar in both groups while the number of mean daily anti-hypertensive substances decreased in the NHD group. In the NHD group, time-averaged serum phosphorus and calcium-phosphorus product were lower than the CHD group. Pulse wave velocity and augmentation index decreased in the NHD group (from 11.02 perpendicular to 2.51 m/s to 9.61 perpendicular to 2.39 m/s and from 28.8 perpendicular to 10.3% to 26.2 perpendicular to 12.1%; p = 0.008 and p = 0.04, respectively). While augmentation index increased in the CHD group (28.0 +/- 9.4 to 31.0 +/- 10.7%, p = 0.02), pulse wave velocity did not change. Subendocardial viability ratio and ejection duration improved in the NHD group (from 135 +/- 28 to 143 +/- 25%, p = 0.01 and from 294 +/- 34 ms to 281 +/- 34 ms, p = 0.003, respectively), accompanied by regression of left ventricular mass index. In multiple stepwise linear regression analyses, NHD was associated with improvements in augmentation index, ejection duration and subendocardial viability ratio. Conclusions: These data indicate that arterial stiffness is ameliorated by implementation of longer hemodialysis sessions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.Öğe The effects of two different blood pressure control strategies on cardiac structures and functions in hemodialysis patients(Oxford Univ Press, 2007) Kayikcioglu, Meral; Tumuklu, Murat; Asci, Gulay; Toz, Huseyin; Ozdogan, Oner; Bozkurt, Devrim; Kos, Timur; Duman, Soner; Ozkahya, Mehmet; Can, Levent; Basci, Ali; Ok, ErcanÖğe The genus Crocus, series Crocus (Iridaceae) in Turkey and 2 East Aegean islands: a genetic approach(2014) Erol, Osman; Akkale, Hilal Betül Kaya; Şık, Levent; Tuna, Metin; Can, Levent; Tanyolaç, Muhammed BahattinIn this study, a total of 26 Crocus specimens from different locations across Turkey and 2 East Aegean islands (Chios and Samos) were analyzed using 12 amplified fragment length polymorphism (AFLP) primer combinations to obtain information on genetic diversity, population structure, and genetic relationships. A total of 369 polymorphic AFLP bands were generated and scored as binary data. Genetic similarities were determined. Cluster analysis revealed 4 major groups among the 26 genotypes examined in this study. the nuclear DNA contents (2C) of the 26 Crocus specimens were found to range from 5.08 pg in C. asumaniae to 9.75 pg in C. sativus. Polymorphic information content (PIC) values were used to examine the capacity of the various primer pairs to amplify polymorphisms in the Crocus specimens. the PIC values ranged from 0.218 (M-CAA/E-AGC) to 0.512 (M-CAT/E-AAG) and showed an average of 0.34. in sum, we herein used AFLP analysis to identify a high level of polymorphism among Crocus specimens collected from various locations in Turkey and Greece, and our structural analysis yielded 2 reconstructed populations. These findings provide new insight into the relationships among different Crocus genotypes and show that AFLP analysis can be useful for Crocus diversity studies.Öğe The genus Crocus, series Crocus (Iridaceae) in Turkey and 2 East Aegean islands: a genetic approach(Tubitak Scientific & Technical Research Council Turkey, 2014) Erol, Osman; Kaya, Hilal Betul; Sik, Levent; Tuna, Metin; Can, Levent; Tanyolac, Muhammed BahattinIn this study, a total of 26 Crocus specimens from different locations across Turkey and 2 East Aegean islands (Chios and Samos) were analyzed using 12 amplified fragment length polymorphism (AFLP) primer combinations to obtain information on genetic diversity, population structure, and genetic relationships. A total of 369 polymorphic AFLP bands were generated and scored as binary data. Genetic similarities were determined. Cluster analysis revealed 4 major groups among the 26 genotypes examined in this study. The nuclear DNA contents (2C) of the 26 Crocus specimens were found to range from 5.08 pg in C. asumaniae to 9.75 pg in C. sativus. Polymorphic information content (PIC) values were used to examine the capacity of the various primer pairs to amplify polymorphisms in the Crocus specimens. The PIC values ranged from 0.218 (M-CAA/E-AGC) to 0.512 (M-CAT/E-AAG) and showed an average of 0.34. In sum, we herein used AFLP analysis to identify a high level of polymorphism among Crocus specimens collected from various locations in Turkey and Greece, and our structural analysis yielded 2 reconstructed populations. These findings provide new insight into the relationships among different Crocus genotypes and show that AFLP analysis can be useful for Crocus diversity studies.Öğe Hereditary thrombophilia (factor V R2-mutation) as a contributing factor in premature myocardial infarction associated with pregnancy(Turkish Soc Cardiology, 2014) Kayikcioglu, Meral; Yavuzgil, Oguz; Eroglu, Zuhal; Onay, Huseyin; Ergenoglu, Mete; Can, LeventÖğe Negative impact of COVID-19 pandemic on the lifestyle and management of patients with homozygous familial hypercholesterolemia(Elsevier Science Inc, 2020) Kayikcioglu, Meral; Tokgozoglu, Lale; Tuncel, Ozlem Kuman; Pirildar, Sebnem; Can, Levent[No Abstract Available]Öğe PCSK 9 gain-of-function mutations (R496W and D374Y) and clinical cardiovascular characteristics in a cohort of Turkish patients with familial hypercholesterolemia(Turkish Soc Cardiology, 2017) Kaya, Esra; Kayikcioglu, Meral; Vardarli, Asli Tetik; Eroglu, Zuhal; Payzin, Serdar; Can, LeventObjective: The molecular basis of the mutations in the PCSK9 gene that produces familial hypercholesterolemia (FH) in the Turkish population is unknown. This study was conducted to determine the presence of four different PCSK9 gain-of-function (GOF) mutations (F216L, R496W, S127R, and D374Y) in a group of patients with FH. Methods: A total of 80 consecutive patients with FH (mean age: 56 +/- 11 years; mean maximum LDL cholesterol: 251 +/- 76 mg/dL) were included in the study. Patients with FH were diagnosed according to the Dutch Lipid Clinic Network criteria based on serum cholesterol levels, personal and family histories of cardiovascular disease, tendon xanthomas, and genetic analysis. To identify F216L, R496W, S127R, and D374Y mutations of the PCSK9 gene, high-resolution melting analysis was performed on isolated DNAs. Results: : Of the 80 patients, there were 11 patients (13.8%) with PCSK9 GOF mutations. Detected mutations were D374Y mutation in four (5.0%) patients and R496W in seven patients (8.7%). Only one patient was homozygous for R496W mutation. The other two GOF mutations (S127R and F216 variants) were not detected. There was no significant difference with regard to demographic characteristics and CV disease risk factors and clinical course of the disease between the PCSK9 mutation-positive and PCSK9 mutation-negative groups. Conclusion: This is the first study from a Turkish FH cohort, revealing a higher frequency (approximately 14%) of two PCSK9 GOF mutations (D374Y and R496W) and a different disease course compared to the world literature.Öğe Pseudonormalization: clinical, electrocardiographic, echocardiographic, and angiographic characteristics(Turkish Soc Cardiology, 2007) Ulucan, Cem; Yavuzgil, Oguz; Kayikcioglu, Meral; Can, Levent; Payzm, Serdar; Kultursay, Hakan; Soydan, Inan; Hasdemir, CanObjective: Spontaneous pseudonormalization (PN) is a unique 12-lead electrocardiography (ECG) finding which has been reported to be associated with severe, transmural myocardial ischemia. To date, a paucity of data exists about the incidence and clinical characteristics of patients with PN. Therefore the aim of this study was to investigate the incidence and the electrocardiographic, echocardiographic, and angiographic characteristics of patients with PN. Methods: Clinical, laboratory, electrocardiographic, echocardiographic, and angiographic characteristics of 12 consecutive patients with PN on 12-lead ECG (Group 1) were compared with patients (Group 2, n = 28) presenting with acute coronary syndrome (ACS) associated with ST-T wave changes without PN. Results: All patients presented with chest pain. The incidence of PN among patients presenting with ACS was 1%. Pseudonormalization was present in precordial leads in 11 and in inferior leads in 1 patient. Nine out of 12 (75%) patients in Group 1, 16 out of 28 (57%) patients in Group 2 had elevation of cardiac enzymes compatible with acute myocardial infarction. Severely narrowed or totally occluded ischemia and/or infarction-related coronary arteries were present in all patients in Group 1, in 20 (71%) patients in Group 2. Three patients in Group 1 and one patient in Group 2 had coronary artery thrombus formation. Group 1 patients had worse coronary collateral grading in comparison to Group 2 patients. Conclusion: Pseudonormalization is a rare entity and it is typically associated with severely narrowed or totally occluded coronary arteries along with thrombus formation, and poor coronary collateral development.Öğe THE RELATIONSHIP BETWEEN LIPOPROTEIN A AND AORTIC CALSIFICATION IN PATIENTS WITH HYPERCHOLESTEROLEMIA(Elsevier Ireland Ltd, 2017) Huseynov, Rashad; Kayikcioglu, Meral; Bayraktaroglu, Selen; Can, Levent; Payzin, SerdarÖğe Right ventricular free-wall longitudinal speckle tracking strain in patients with pulmonary arterial hypertension under specific treatment(Wiley, 2017) Kemal, Hatice S.; Kayikcioglu, Meral; Kultursay, Hakan; Vuran, Ozcan; Nalbantgil, Sanem; Mogulkoc, Nesrin; Can, LeventBackground Right ventricular (RV) dysfunction is a major determinant of outcomes in patients with pulmonary arterial hypertension (PAH), although the optimal measure of RV function is poorly defined. We evaluated the utility of RV free-wall speckle tracking strain as an assessment tool for RV function in patients with PAH who are already under specific treatment compared with conventional echocardiographic parameters and investigated the relationship of RV free-wall strain with clinical hemodynamic parameters of RV performance. Methods Right ventricular free-wall strain was evaluated in 92 patients (Group-1 and Group-4 pulmonary hypertension) who were on PAH-specific treatment for at least 3 months. Right atrial (RA) area, RV FAC, TAPSE, tricuspid S, functional class, 6-minute walking distance, and NT-proBNP were studied. The mean duration of follow-up was 222 +/- 133 days. Results All patients were under PAH-specific treatment, and mean RV free-wall strain was -13.16 +/- 6.3%. RV free-wall strain correlated well with functional class (r=.312, P=.01), NT-proBNP (r=.423, P=.0001), RA area (r=.427, P=.0001), FAC (r=-.637, P=.0001), TAPSE (r=-.524, P=.0001), tricuspid S (r=-.450, P=.0001), 6-minute walking distance (r=-.333, P=.002). RV free-wall strain significantly correlated with all follow-up adverse events, death, and clinical right heart failure (RHF) (P=.04, P=.03, P=.02, respectively). According to the receiver operator characteristic analysis, the cutoff value for RV free-wall strain for the development of clinical RHF was -12.5% (sensitivity: 71%, specificity: 67%) and for all cardiovascular adverse events (death included) was -12.5% (sensitivity: 54%, specificity: 64%). Conclusion Assessment of RV free-wall strain is a feasible, easy-to-perform method and may be used as a predictor of RHF, clinical deterioration, and mortality in patients already under PAH-specific treatment.Öğe The risk factors and associations of coronary artery calcification in hemodialysis patients(Oxford Univ Press, 2007) Asci, Gulay; Savas, Recep; Duman, Soner; Kayikcioglu, Meral; Ozkahya, Mehmet; Ozdogan, Oner; Can, Levent; Celik, Gulperi; Toz, Huseyin; Sezis, Meltem; Sipahi, Savas; Ok, Ercan