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Öğe Can Palosuran, as an Urotensin II Receptor Antagonist, Protect Kidneys from Calcineurins(Lippincott Williams & Wilkins, 2012) Bozkurt, D.; Olukman, M.; Hur, E.; Bicak, S.; Tuna, S.; Sen, S.; Akcicek, F.; Duman, S.Öğe A Case of Acute Q Fever Presenting with Abdominal Pain and Developing Myocarditis(DOC Design and Informatics Co. Ltd., 2023) Bozkurt, Ç.; Gurbanov, A.; Yağmur, B.; Kılınçer-Bozgül, Ş.M.; Bozkurt, D.Coxiella burnetii is the cause of Q fever, which is a zoonosis. Although the disease is mostly asymptomatic, it can prog-ress to different clinical forms. Myocarditis is rarely seen in acute Q fever. In this report, we present a 40-year-old male patient who applied to the emergency department with complaints of abdominal pain and fever and was followed with the diagnosis of cholangitis. He was later transferred to the intensive care unit after developing heart failure and was diagnosed with Q fever myocarditis. We present this case to bring attention to the severe clinical course and the unusual onset of Q fever. © 2023, DOC Design and Informatics Co. Ltd.. All rights reserved.Öğe Non steroidal antiinflammatory drugs may be harmful to normal kidneys: experimental surgery model(Lithographia, 2012) Hur, E.; Duman, E.; Bozkurt, D.; Sozmen, E.; Sen, S.; Taskin, H.; Timur, O.; Kaya, S. O.; Duman, S.Background and aim: The exact effect of analgesics on normal kidneys is not known yet. We aimed to evaluate the impression of non steroidal antiinflammatory drugs (NSAID) used post-operatively on kidneys, in rat (tracheotomy) model. Methods: Twenty-five non-uremic male wistar albino rats were included. For 18 rats, tracheotomy was performed and divided into two groups. First group, NSAID (diclofenac 10 mg/kg/day intramuscular (im)) (NSAID, n=8); second group isotonic (im)(Control, n=10) were administered for a week. For third group (Histological control, n=7) in order to evaluate normal histology neither surgery nor medication were applied. At the end (7th day), 24 hours urine collected then, blood samples were taken by intracardiac punction and were sacrified. One of the kidneys fixed for histological evaluation, the other was preserved for the measurements of tissue enzyme levels. Lipid peroxidation products and antioxidant enzyme levels were measured both from plasma and renal tissues. Histologically inflammation, regeneration, degeneration assessed semiquatitativelly and immunohistochemical dyes were applied. Results: Hemoglobin thiobarbituric acid reactive substance level indicating the increase of lipid peroxidation in NSAID group was higher than control group (673 +/- 204 vs.373 +/- 27nmol/gHb respectively, p>0.05). Superoxide dismutase (one of the antioxidant enzymes responsible for reduction of reactive oxygen substances) and serum nitrate levels were lower in NSAID groups (700 +/- 68 vs.1371 +/- 164U/gHb and 26 +/- 4.4 vs.50.8 +/- 6.8 mu mol/mL respectively, p<0.05). Although tissue levels were parallel to plasma levels but the difference wasn't significant. In histological assessment degeneration was present only in NSAID group (1.3 +/- 0.6 vs.0.0 +/- 0, p<0.05). Inflammation were lower than the control group (0.8 +/- 0.4 vs.1.2 +/- 0.2, p>0.05). Cyclooxygenase-2 expression was disappeared in NSAID group. Conclusions: NSAIDs mostly used post-operatively for analgesia, may cause unfavorable effects on kidneys by oxidative stress. Hippokratia. 2012; 16 (2): 160-165Öğe Osteoprotegerin and matrix-gla protein: Independent predictors of mortality in hemodialyis patients(Karger, 2008) Sevinc, E.; Kircelli, F.; Asci, G.; Yilmaz, M.; Bozkurt, D.; Ozkahya, M.; Basci, A.; Ok, E.Öğe Performance Evaluation of Machine Learning Algorithms for Sarcopenia Diagnosis in Older Adults(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Ozgur, S.; Altinok, Y.A.; Bozkurt, D.; Saraç, Z.F.; Akçiçek, S.F.Background: Sarcopenia is a progressive and generalized skeletal muscle disorder. Early diagnosis is necessary to reduce the adverse effects and consequences of sarcopenia, which can help prevent and manage it in a timely manner. The aim of this study was to identify the important risk factors for sarcopenia diagnosis and compare the performance of machine learning (ML) algorithms in the early detection of potential sarcopenia. Methods: A cross-sectional design was employed for this study, involving 160 participants aged 65 years and over who resided in a community. ML algorithms were applied by selecting 11 features—sex, age, BMI, presence of hypertension, presence of diabetes mellitus, SARC-F score, MNA score, calf circumference (CC), gait speed, handgrip strength (HS), and mid-upper arm circumference (MUAC)—from a pool of 107 clinical variables. The results of the three best-performing algorithms were presented. Results: The highest accuracy values were achieved by the ALL (male + female) model using LightGBM (0.931), random forest (RF; 0.927), and XGBoost (0.922) algorithms. In the female model, the support vector machine (SVM; 0.939), RF (0.923), and k-nearest neighbors (KNN; 0.917) algorithms performed the best. Regarding variable importance in the ALL model, the last HS, sex, BMI, and MUAC variables had the highest values. In the female model, these variables were HS, age, MUAC, and BMI, respectively. Conclusions: Machine learning algorithms have the ability to extract valuable insights from data structures, enabling accurate predictions for the early detection of sarcopenia. These predictions can assist clinicians in the context of predictive, preventive, and personalized medicine (PPPM). © 2023 by the authors.Öğe Trimethylaminuria (fish malodour syndrome) in chronic renal failure(Lithographia, 2012) Hur, E.; Gungor, O.; Bozkurt, D.; Bozgul, S. M. K.; Dusunur, F.; Caliskan, H.; Berdeli, A.; Akcicek, F.; Basci, A.; Duman, S.Trimethylaminuria (fish malodour syndrome) is a rare genetic metabolic disorder presented with a body odour which smells like a decaying fish. This odour is highly objectionable, that can be destructive for the social, and work life of the patient. Trimethylamine is derived from the intestinal bacterial degradation of foods that are rich of choline and carnitine. Trimethylamine is normally oxidised by the liver to odourless trimethylamine N-oxide which is excreted in the urine, so, uremia may worsen the condition. Uremia itself may cause more or less unpleasant odour. Poor uremic control may worsen the odour. We reported this case because Trimethylaminuria is not usually considered in the differential diagnosis of malodour in chronic renal failure and it is the first case that shown the association with Trimethylaminuria and chronic renal failure in the literature. Hippokratia. 2012; 16 (1): 83-85
