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Öğe Diverse effects of ganoderma lucidum in combination with tamoxifen citrate and doxorubicin in MCF-7 breast cancer cells(Wiley-Blackwell, 2016) Atay, S.; Ak, H.; Kalmis, E.; Kayalar, H.; Aydin, H. H.Öğe Effect of complete hilar versus only renal artery clamping on renal histomorphology following ischemia/reperfusion injury in an experimental model(Verduci Publisher, 2016) Umul, M.; Cal, A. C.; Turna, B.; Oktem, G.; Aydin, H. H.OBJECTIVE: To evaluate the effect of temporary complete hilar versus only renal artery clamping with different duration of warm ischemia on renal functions, and possibly identify a "safe" clamping type and duration of renal ischemia. MATERIALS AND METHODS: Fifty male rabbits have been incorporated to study. Rabbits were subjected to ischemia/reperfusion injury by temporary vascular clamping. Reagents were randomized to 3 experimental groups (only renal artery clamping, complete hilar clamping, sham surgery) and sub-groups were determined according to different clamping times (30 and 60 minutes). Median laparotomy and left renal hilus dissection were performed to sham group. Only artery or complete hilar clamping was performed for 30 or 60 minutes by microvascular bulldog clamps to other reagents. Rabbits were sacrificed 10 days after primary surgery and left nephrectomy performed. Nephrectomy materials were evaluated for the level of nitric-oxide synthase (NOS) immunoreactivity, malondialdehyde (MDA) level and superoxide dismutase (SOD) activity and an electron microscopic examination was performed. RESULTS: NOS immunoreactivity was correlated with the temporary clamping time. We also observed that complete hilar vascular clamping entails an increase on NOS immunoreactivity. MDA levels were similar for all experimental surgery groups (p = 0.42). The SOD activity was decreased among all subgroups compared with sham surgery. But the significant decrease occurred in 30 minutes only artery and 30 minutes complete hilar clamping groups in proportion to sham surgery (p = 0.026 and p = 0.019, respectively). CONCLUSIONS: This current study suggested that only renal artery clamping under 30 minutes is more appropriate during renal surgical procedures requiring temporary vascular clamping.Öğe GENOME-WIDE COPY NUMBER VARIATION ANALYSIS IN IDIOPATHIC INTELLECTUAL DISABILITY/MULTIPLE CONGENITAL ANOMALIES(Medecine Et Hygiene, 2014) Pariltay, E.; Durmaz, A.; Durmaz, B.; Aykut, A.; Onay, H.; Ak, H.; Aydin, H. H.; Özkınay, Ferda; Cogulu, O.Genome-wide copy number variation analysis in idiopathic intellectual disability/multiple congenital anomalies: New array technologies have facilitated the analysis of submicroscopic chromosomal imbalances and structural variants. Copy number variation (CNV) analysis can reveal genetic imbalances in up to 10 % of cases involving intellectual disability (ID), with or without multiple congenital anomalies (MCA). Here we present 4 cases, diagnosed by CNV analysis using Affymetrix Genome Wide Human SNP 6.0 array, and their parents. CNVs ranging from 18 to 196 per subject, with a size range of 100kb-6093kb, were detected in all cases. One case revealed inherited CNVs, whilst de novo ins/dels were found in the other three which may be causative factors in the development of clinical pictures. Microarray technology may help to reveal the etiology of ID and is a potentially useful diagnostic tool for patients with ID/MCA.Öğe Investigating expression levels of genes responsible for electron transport chain in uterine fibroid(Wiley-Blackwell, 2013) Tuncal, A.; Aydin, H. H.; Askar, N.; Yeniel, A. Ozgur; Ergenoglu, A. Mete; Akdemir, A.; Celik, H. A.Öğe Investigating the effects of Hericium erinaceus extracts on telomerase activity in MCF-7 cells(Wiley-Blackwell, 2016) Gencalp, D.; Ak, H.; Aydin, H. H.; Kalmis, E.; Kayalar, H.Öğe Investigation of the effects of GW8510 pharmacological inhibitor on in vitro pancreatic cancer model(Wiley, 2019) Gencalp, D.; Ak, H.; Atay, S.; Aydin, H. H.[No abstract available]Öğe IS OVERACTIVE BLADDER MICROVASCULATURE DISEASE A COMPONENT OF SYSTEMIC ATHEROSCLEOROSIS?(Wiley, 2017) Yeniel, A. O.; Ergenoglu, A. M.; Meseri, R.; Kismali, E.; Kavukcu, G.; Ari, A.; Aydin, H. H.; Ak, H.; Atay, S.; Itil, I. M.Öğe Serotonin transporter (5-HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation(Wiley, 2018) Khan, H. L.; Bhatti, S.; Abbas, S.; Khan, Y. L.; Gonzalez, R. M. M.; Aslamkhan, M.; Gonzalez, G. R.; Aydin, H. H.Premature ejaculation is one of the most common sexual disorders in men due to uncontrolled modulation of spinal reflexes controlled by cortico-limbic centers in the brain. In this study, we investigate the combinatorial effects of trinucleotide repeats of androgen receptor and allelic variants of the 5-HTTLPR gene on sex steroids, hypophyseal hormones, sexual performance, and premature ejaculation assessment parameters among evidence-based lifelong premature ejaculation subjects. A total of 271 outpatients (age 26.6 +/- 1.9) consulting for evidence-based lifelong premature ejaculatory dysfunction were selected in this study. The control group consists of 155 men with normal IELT (>4 min). The study revealed that the subjects who have the highest (>= 26) CAG stretches depicted a significantly higher serum oxytocin levels (102.1 pg/ml; n = 126, p < 0.001) compared with the control group (71.2 pg/ml; n = 75, p = <0.001) and patients which have medium (22-25) and short (<= 21) CAG stretches (76.63 ng/ml; n = 64, p n = 81, p < 0.001). Almost 33 (26.1%) lifelong premature ejaculatory patients had AR variant of longer (>= 26) CAG repeats was homozygous for S alleles (SS), 45 (35.7%) was homozygous for L allele (LL), and 48 (38%) had the L/S or S/L genotype of 5-HTTLPR gene. Homozygous (SS) alleles have a significant positive correlation (r = 0.44, p < 0.0001) with the high score of BDI-II (39.1, n = 126, p < 0.001). However, LL alleles have shown a significant positive correlation with PEDT (r = 0.46, p < 0.001) and negative correlation with self-estimated IELT and intercourse satisfaction (r = -0.35, p < 0.001). The innovative study design elaborates that androgen receptor trinucleotide repeats and 5-HTTLPR genotypes have combinatorial impact on hormonal milieu and sexual function regarding evidence-based lifelong premature ejaculatory dysfunction patients.